Roso-Bas Fatima, Alonso-Llobregat Maria Dolores, Bento Leyre, Sanchez-Gonzalez Blanca, Herraez Ines, Garcia-Dilla Pilar, Vallespir Catalina, Rado Francesca, Rodriguez Raquel, Garcia-Pallarols Francesc, Aguirre Irache, Bargay Joan, Sampol Antonia, Salar Antonio, Gutierrez Antonio
Clinical Practice and Biology of the Hematological Malignancies Research Group, IdISBa, Son Espases University Hospital, 07120 Palma de Mallorca, Spain.
Unit of Lymphoma, Department of Hematology, Son Espases University Hospital, 07120 Palma de Mallorca, Spain.
J Clin Med. 2021 Apr 12;10(8):1631. doi: 10.3390/jcm10081631.
Hodgkin lymphoma (HL) is a highly-curable malignancy mostly affecting young people. As far as we know, there is no published study that has analyzed personality profiles in HL nor their potential role in lymphomagenesis, natural history, or response to treatment. We aim to explore the personality traits of HL patients, as well as the prevalence of mental disorders and suicide ideas. We retrospectively identified all alive HL patients from three centers (Son Espases and Son Llatzer University Hospitals and Hospital del Mar of Barcelona) for using NEO Five-Factor Inventory (NEO-FFI) and Personality Inventory for DSM-5 Brief Form. Patients with HL showed significantly higher neuroticism scores and lower conscientiousness, extraversion, and openness. Considering maladaptive personality traits, HL patients showed higher levels of detachment and psychoticism. All of these translated into the fact that HL patients showed more than double the prevalence of mental illnesses (41%) and more than triple the prevalence of suicidal ideation or attempts than the general population (15 and 6%, respectively). An exploratory analysis of biomarkers associated with HL personality traits showed that higher scores of neuroticism correlated with more elevated erythrocyte sedimentation rate (ESR) and red cell distribution width (RDW), suggesting a potential link between neuroticism and proinflammatory activity in HL.
霍奇金淋巴瘤（HL）是一种高度可治愈的恶性肿瘤，主要影响年轻人。据我们所知，尚无已发表的研究分析过HL患者的人格特征及其在淋巴瘤发生、自然病程或治疗反应中的潜在作用。我们旨在探究HL患者的人格特质，以及精神障碍和自杀观念的发生率。我们通过回顾性研究，从三个中心（Son Espases和Son Llatzer大学医院以及巴塞罗那的德尔马医院）确定了所有在世的HL患者，使用NEO五因素问卷（NEO-FFI）和DSM-5简版人格问卷。HL患者的神经质得分显著更高，而尽责性、外向性和开放性得分更低。考虑到适应不良的人格特质，HL患者表现出更高水平的疏离感和精神质。所有这些都导致HL患者的精神疾病患病率（41%）是普通人群的两倍多，自杀观念或自杀企图的患病率（分别为15%和6%）是普通人群的三倍多。一项对与HL人格特质相关的生物标志物的探索性分析表明，神经质得分越高，红细胞沉降率（ESR）和红细胞分布宽度（RDW）越高，这表明神经质与HL中的促炎活动之间可能存在联系。
