Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, UCLouvain, B-1200 Brussels, Belgium.
Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Louvain Drug Research Institute, UCLouvain, B-1200 Brussels, Belgium.
Nutrients. 2021 Apr 24;13(5):1436. doi: 10.3390/nu13051436.
Berberine and curcumin, used as food additives or food supplements, possess interesting anti-inflammatory and antioxidant properties. We tested the potential protective effect of both phytochemicals in genetically obese mice and we determined whether these effects can be related to the modulation of gut functions and microbiota. mice were fed a standard diet supplemented with or without 0.1% berberine and/or 0.3% curcumin for 4 weeks. By using targeted qPCR, we found that cecal content of spp. and spp. increased mainly upon berberine supplementation. Genes involved in innate immunity (), mucus production () and satietogenic peptide production ( and were upregulated in the colon of mice treated with both phytochemicals. Berberine supplementation alone reduced food intake, body weight gain, hypertriglyceridemia and hepatic inflammatory and oxidative stress markers, thus lessening hepatic injury. The increase in spp. and spp. was correlated with the improvement of gut barrier function and with the improvement of hepatic inflammatory and oxidative stresses in obese mice. These data support the fact that non-carbohydrate phytochemicals may modulate the gut microbiota in obesity and related gut and hepatic alterations.
小檗碱和姜黄素，用作食品添加剂或膳食补充剂，具有有趣的抗炎和抗氧化特性。我们测试了这两种植物化学物质在遗传性肥胖小鼠中的潜在保护作用，并确定这些作用是否与肠道功能和微生物群的调节有关。将肥胖小鼠分为两组，分别喂食标准饮食，其中一组添加 0.1%小檗碱和/或 0.3%姜黄素，持续 4 周。通过使用靶向 qPCR，我们发现盲肠内容物中的 spp. 和 spp. 主要在添加小檗碱时增加。参与固有免疫（）、粘液产生（）和饱腹肽产生（和）的基因在接受两种植物化学物质治疗的小鼠结肠中上调。单独补充小檗碱可减少食物摄入、体重增加、高甘油三酯血症以及肝脏炎症和氧化应激标志物，从而减轻肝脏损伤。 spp. 和 spp. 的增加与肠道屏障功能的改善以及肥胖小鼠肝脏炎症和氧化应激的改善相关。这些数据支持这样一个事实，即非碳水化合物植物化学物质可能调节肥胖及其相关的肠道和肝脏改变中的肠道微生物群。
