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褐藻多酚的抗真菌和杀幼虫活性。

Antifungal and Larvicidal Activities of Phlorotannins from Brown Seaweeds.

机构信息

Seafood Research Center, Industry-Academic Cooperation Foundation, Silla University, 606, Advanced Seafood Processing Complex, Wonyang-ro, Amnam-dong, Seo-gu, Busan 49277, Korea.

Department of Food Biotechnology, College of Medical and Life Sciences, Silla University, 140, Baegyang-daero 700beon-gil, Sasang-gu, Busan 46958, Korea.

出版信息

Mar Drugs. 2021 Apr 16;19(4):223. doi: 10.3390/md19040223.

DOI:10.3390/md19040223
PMID:33923448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8073715/
Abstract

Phlorotannins are secondary metabolites produced by brown seaweeds with antiviral, antibacterial, antifungal, and larvicidal activities. Phlorotannins' structures are formed by dibenzodioxin, ether and phenyl, ether, or phenyl linkages. The polymerization of phlorotannins is used to classify and characterize. The structural diversity of phlorotannins grows as polymerization increases. They have been characterized extensively with respect to chemical properties and functionality. However, review papers of the biological activities of phlorotannins have focused on their antibacterial and antiviral effects, and reviews of their broad antifungal and larvicidal effects are lacking. Accordingly, evidence for the effectiveness of phlorotannins as antifungal and larvicidal agents is discussed in this review. Online databases (ScienceDirect, PubMed, MEDLINE, and Web of Science) were used to identify relevant articles. In total, 11 articles were retrieved after duplicates were removed and exclusion criteria were applied. Phlorotannins from brown seaweeds show antifungal activity against dermal and plant fungi, and larvicidal activity against mosquitos and marine invertebrate larvae. However, further studies of the biological activity of phlorotannins against fungal and parasitic infections in aquaculture fish, livestock, and companion animals are needed for systematic analyses of their effectiveness. The research described in this review emphasizes the potential applications of phlorotannins as pharmaceutical, functional food, pesticide, and antifouling agents.

摘要

藻多酚是由褐藻产生的次生代谢物，具有抗病毒、抗菌、抗真菌和杀幼虫活性。藻多酚的结构由二苯并二恶英、醚和苯、醚或苯键形成。藻多酚的聚合用于分类和表征。随着聚合度的增加，藻多酚的结构多样性增加。它们的化学性质和功能已经得到了广泛的研究。然而，藻多酚的生物活性综述论文主要集中在其抗菌和抗病毒作用上，缺乏对其广泛的抗真菌和杀幼虫作用的综述。因此，本文讨论了藻多酚作为抗真菌和杀幼虫剂的有效性。利用在线数据库（ScienceDirect、PubMed、MEDLINE 和 Web of Science）来确定相关文章。在去除重复项并应用排除标准后，共检索到 11 篇文章。褐藻中的藻多酚对皮肤和植物真菌具有抗真菌活性，对蚊子和海洋无脊椎动物幼虫具有杀幼虫活性。然而，需要对水产养殖鱼类、家畜和伴侣动物的真菌和寄生虫感染中藻多酚的生物活性进行进一步研究，以便对其有效性进行系统分析。本综述中描述的研究强调了藻多酚作为药物、功能性食品、农药和防污剂的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/7226a24ff145/marinedrugs-19-00223-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/80d475ac54a8/marinedrugs-19-00223-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/ea8249de10f9/marinedrugs-19-00223-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/7226a24ff145/marinedrugs-19-00223-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/80d475ac54a8/marinedrugs-19-00223-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/ea8249de10f9/marinedrugs-19-00223-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e1/8073715/7226a24ff145/marinedrugs-19-00223-g003.jpg

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