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Frailty and reduced gait speed are independently related to mortality of cirrhotic patients in long-term follow-up.虚弱和步态速度减慢与肝硬化患者长期随访中的死亡率独立相关。
Ann Hepatol. 2021 Nov-Dec;25:100327. doi: 10.1016/j.aohep.2021.100327. Epub 2021 Feb 14.
2
Refining dual-energy x-ray absorptiometry data to predict mortality among cirrhotic outpatients: A retrospective study.对双能 X 射线吸收法数据进行精细化处理以预测肝硬化门诊患者的死亡率：一项回顾性研究。
Nutrition. 2021 May;85:111132. doi: 10.1016/j.nut.2020.111132. Epub 2020 Dec 31.
3
ESPEN practical guideline: Clinical nutrition in liver disease.ESPEN 实践指南：肝病的临床营养。
Clin Nutr. 2020 Dec;39(12):3533-3562. doi: 10.1016/j.clnu.2020.09.001. Epub 2020 Oct 27.
4
Sarcopenia Severity Based on Computed Tomography Image Analysis in Patients with Cirrhosis.基于计算机断层扫描图像分析的肝硬化患者肌肉减少症严重程度。
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Sarcopenia in Cirrhosis: Fallout on Liver Transplantation.肝硬化中的肌肉减少症：对肝移植的影响。
J Clin Exp Hepatol. 2020 Sep-Oct;10(5):467-476. doi: 10.1016/j.jceh.2019.12.003. Epub 2019 Dec 31.
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Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease.肌肉减少症和身体活动不足对非酒精性脂肪性肝病患者死亡率的影响。
JHEP Rep. 2020 Aug 15;2(6):100171. doi: 10.1016/j.jhepr.2020.100171. eCollection 2020 Dec.
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Resistance Exercise, Electrical Muscle Stimulation, and Whole-Body Vibration in Older Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials.老年人的抗阻运动、肌肉电刺激和全身振动：随机对照试验的系统评价和荟萃分析
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Phase Angle From Bioelectrical Impedance for the Assessment of Sarcopenia in Cirrhosis With or Without Ascites.基于生物电阻抗的相位角评估肝硬化伴或不伴腹水患者的肌肉减少症。
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Gender difference of aging performance decay rate in normalized Masters World Records of Athletics: much less than expected.田径大师级世界纪录标准化中衰老表现衰退率的性别差异：远低于预期。
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Incorporation of frailty estimated by gait speed within MELD-Na and the predictive potential for mortality in cirrhosis.将通过步速估算的衰弱程度纳入终末期肝病模型钠评分（MELD-Na）及其对肝硬化患者死亡率的预测潜力。
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慢性肝病中肌肉减少症的定义。

Definition of Sarcopenia in Chronic Liver Disease.

作者信息

Son Seong Wan, Song Do Seon, Chang U Im, Yang Jin Mo

机构信息

Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

出版信息

Life (Basel). 2021 Apr 16;11(4):349. doi: 10.3390/life11040349.

DOI:10.3390/life11040349
PMID:33923561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8074027/
Abstract

Sarcopenia, which is characterized by decline in muscle mass, muscle strength, and physical performance, is common in patients with chronic liver disease (CLD) and is associated with poor clinical outcomes. Several consensus definitions for community-dwelling elderly people have been proposed, and these recommend the use of various tools and tests to assess muscle properties and performance. These measurement tools have also been applied in patients with CLD and have been useful for predicting prognosis. However, sarcopenia and its diagnostic criteria specific to patients with CLD have not yet been clearly defined. In addition, fluid retention and body composition should be considered when sarcopenia is assessed in patients with CLD. This review aims to introduce definitions of sarcopenia and diagnostic tools used in patients with CLD.

摘要

肌肉减少症的特征是肌肉质量、肌肉力量和身体机能下降，在慢性肝病（CLD）患者中很常见，并且与不良临床结局相关。针对社区居住老年人已经提出了几种共识定义，这些定义推荐使用各种工具和测试来评估肌肉特性和机能。这些测量工具也已应用于CLD患者，并有助于预测预后。然而，CLD患者特有的肌肉减少症及其诊断标准尚未明确界定。此外，在评估CLD患者的肌肉减少症时，应考虑液体潴留和身体成分。本综述旨在介绍CLD患者中肌肉减少症的定义和诊断工具。