Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Department of Women's and Children's Health, Sapienza University of Rome, 00161 Rome, Italy.
Int J Mol Sci. 2021 Apr 16;22(8):4127. doi: 10.3390/ijms22084127.
In the last decade, the widespread application of shotgun metagenomics provided extensive characterization of the bacterial "dark matter" of the gut microbiome, propelling the development of dedicated, standardized bioinformatic pipelines and the systematic collection of metagenomic data into comprehensive databases. The advent of next-generation sequencing also unravels a previously underestimated viral population (virome) present in the human gut. Despite extensive efforts to characterize the human gut virome, to date, little is known about the childhood gut virome. However, alterations of the gut virome in children have been linked to pathological conditions such as inflammatory bowel disease, type 1 diabetes, malnutrition, diarrhea and celiac disease.
在过去的十年中， shotgun 宏基因组学的广泛应用广泛描述了肠道微生物组的细菌“暗物质”，推动了专门的、标准化的生物信息学管道的发展，并将宏基因组数据系统地收集到综合数据库中。下一代测序的出现也揭示了人类肠道中以前被低估的病毒群体（病毒组）。尽管人们已经做出了广泛的努力来描述人类肠道病毒组，但迄今为止，人们对儿童肠道病毒组知之甚少。然而，儿童肠道病毒组的改变与炎症性肠病、1 型糖尿病、营养不良、腹泻和乳糜泻等病理状况有关。
