Ali Muhammad, Benfante Viviana, Stefano Alessandro, Yezzi Anthony, Di Raimondo Domenico, Tuttolomondo Antonino, Comelli Albert
Ri.MED Foundation, Via Bandiera 11, 90133 Palermo, Italy.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Molecular and Clinical Medicine, University of Palermo, 90127 Palermo, Italy.
Life (Basel). 2023 Jan 28;13(2):361. doi: 10.3390/life13020361.
Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kinds of receptors and membranes. They modulate different signal cascades and interact with the enzymes responsible for CD and RA. These interactions involve cellular machinery, from cell membranes to major nuclear components, and provide information on their beneficial effects on health. These actions provide evidence for their pharmaceutical exploitation in the treatment of CD and RA. In this review, we discuss different pathways, modulated by polyphenols, which are involved in CD and RA. A search of the most recent relevant publications was carried out with the following criteria: publication date, 2012-2022; language, English; study design, in vitro; and the investigation of polyphenols present in extra virgin olive, grapes, and spices in the context of RA and CD, including, when available, the underlying molecular mechanisms. This review is valuable for clarifying the mechanisms of polyphenols targeting the pathways of senescence and leading to the development of CD and RA treatments. Herein, we focus on research reports that emphasize antioxidant properties.
多酚因其在预防和管理包括癌症疾病（CD）和类风湿性关节炎（RA）在内的各种疾病方面具有显著效果而受到广泛关注。它们是存在于水果、蔬菜和香料中的天然有机物质。多酚与各种受体和膜相互作用。它们调节不同的信号级联反应，并与负责CD和RA的酶相互作用。这些相互作用涉及从细胞膜到主要核成分的细胞机制，并提供了它们对健康有益作用的相关信息。这些作用为它们在治疗CD和RA方面的药物开发提供了证据。在本综述中，我们讨论了由多酚调节的、与CD和RA相关的不同途径。按照以下标准对最新的相关出版物进行了检索：出版日期为2012年至2022年；语言为英语；研究设计为体外研究；以及在RA和CD背景下对特级初榨橄榄油、葡萄和香料中存在的多酚进行研究，包括在可行的情况下研究其潜在分子机制。本综述对于阐明多酚靶向衰老途径并推动CD和RA治疗方法发展的机制具有重要价值。在此，我们重点关注强调抗氧化特性的研究报告。
