Ooi Soo Liang, Pak Sok Cheon, Micalos Peter S, Schupfer Emily, Lockley Catherine, Park Mi Houn, Hwang Sung-Joo
School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia.
EROM R&D Center, EROM Co., Ltd., Chuncheon-si 24427, Gangwon-do, Korea.
Molecules. 2021 Apr 27;26(9):2539. doi: 10.3390/molecules26092539.
Rice bran arabinoxylan compound (RBAC) is derived from defatted rice bran hydrolyzed with mycelial enzyme. It has been marketed as a functional food and a nutraceutical with health-promoting properties. Some research has demonstrated this rice bran derivative to be a potent immunomodulator, which also possesses anti-inflammatory, antioxidant, and anti-angiogenic properties. To date, research on RBAC has predominantly focused on its immunomodulatory action and application as a complementary therapy for cancer. Nonetheless, the clinical applications of RBAC can extend beyond cancer therapy. This article is a narrative review of the research on the potential benefits of RBAC for cancer and other health conditions based on the available literature. RBAC research has shown it to be useful as a complementary treatment for cancer and human immunodeficiency virus infection. It can positively modulate serum glucose, lipid and protein metabolism in diabetic patients. Additionally, RBAC has been shown to ameliorate irritable bowel syndrome and protect against liver injury caused by hepatitis or nonalcoholic fatty liver disease. It can potentially ease symptoms in chronic fatigue syndrome and prevent the common cold. RBAC is safe to consume and has no known side effects at the typical dosage of 2-3 g/day. Nevertheless, further research in both basic studies and human clinical trials are required to investigate the clinical applications, mechanisms, and effects of RBAC.
米糠阿拉伯木聚糖化合物（RBAC）源自用菌丝体酶水解的脱脂米糠。它已作为一种具有促进健康特性的功能性食品和营养保健品上市。一些研究表明，这种米糠衍生物是一种强大的免疫调节剂，还具有抗炎、抗氧化和抗血管生成特性。迄今为止，对RBAC的研究主要集中在其免疫调节作用以及作为癌症辅助治疗的应用。然而，RBAC的临床应用可以扩展到癌症治疗之外。本文是基于现有文献对RBAC对癌症和其他健康状况潜在益处的研究的叙述性综述。RBAC研究表明，它可作为癌症和人类免疫缺陷病毒感染的辅助治疗方法。它可以对糖尿病患者的血清葡萄糖、脂质和蛋白质代谢产生积极调节作用。此外，RBAC已被证明可改善肠易激综合征，并预防由肝炎或非酒精性脂肪肝病引起的肝损伤。它可能缓解慢性疲劳综合征的症状并预防普通感冒。RBAC食用安全，在每天2 - 3克的典型剂量下没有已知的副作用。然而，仍需要在基础研究和人体临床试验中进行进一步研究，以调查RBAC的临床应用、机制和效果。
