Department of Bioscience, Federal University of São Paulo, Santos, São Paulo, Brazil.
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.
Phytother Res. 2021 Sep;35(9):4988-5006. doi: 10.1002/ptr.7131. Epub 2021 Apr 29.
The SARS-CoV-2 virus, responsible for COVID-19, spread rapidly worldwide and became a pandemic in 2020. In some patients, the virus remains in the respiratory tract, causing pneumonia, respiratory failure, acute respiratory distress syndrome (ARDS), and sepsis, leading to death. Natural flavonoids (aglycone and glycosides) possess broad biological activities encompassing antiinflammatory, antiviral, antitumoral, antiallergic, antiplatelet, and antioxidant effects. While many studies have focused on the effects of natural flavonoids in experimental models, reports based on clinical trials are still insufficient. In this review, we highlight the effects of flavonoids in controlling pulmonary diseases, particularly the acute respiratory distress syndrome, a consequence of COVID-19, and their potential use in coronavirus-related diseases. Furthermore, we also focus on establishing a relationship between biological potential and chemical aspects of related flavonoids and discuss several possible mechanisms of action, pointing out some possible effects on COVID-19.
导致 COVID-19 的 SARS-CoV-2 病毒在全球范围内迅速传播，并于 2020 年成为大流行。在一些患者中，病毒仍存在于呼吸道中，导致肺炎、呼吸衰竭、急性呼吸窘迫综合征 (ARDS) 和败血症，导致死亡。天然类黄酮（苷元和糖苷）具有广泛的生物活性，包括抗炎、抗病毒、抗肿瘤、抗过敏、抗血小板和抗氧化作用。虽然许多研究都集中在天然类黄酮在实验模型中的作用上，但基于临床试验的报告仍然不足。在这篇综述中，我们强调了类黄酮在控制肺部疾病（特别是 COVID-19 引起的急性呼吸窘迫综合征）方面的作用，以及它们在冠状病毒相关疾病中的潜在用途。此外，我们还重点研究了相关类黄酮的生物学潜力和化学方面之间的关系，并讨论了几种可能的作用机制，指出了对 COVID-19 的一些可能影响。
