Department of Infectious Diseases and Clinical Microbiology, Bismil State Hospital, Diyarbakır, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Batman Medical Park Hospital, Batman, Turkey.
Int J Clin Pract. 2021 Aug;75(8):e14292. doi: 10.1111/ijcp.14292. Epub 2021 May 13.
The objective of the study was to evaluate the serum levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 in chronic HBV-infected patients.
The present study was a single centre, prospective and randomised controlled trial. Twenty healthy volunteers and thirty HBeAg-negative patients with planned liver biopsy and treatment-naive diagnosed with chronic hepatitis B (CHB) were included in the study. TNF-α, IL-1β and IL-6 levels were measured in the serum of CHB patient and control groups using an ELISA. Results were compared statistically using a Mann-Whitney U test.
The mean age of the CHB group (20 men, 10 women) and the control group (10 men, 10 women) was 33.3 ± 9.7 (17-55) and 26.1 ± 12.3 (16-57), respectively. When the two groups were compared with the Mann-Whitney U-test, TNF-α and IL-6 levels were found to be significantly higher in the CHB group compared to the control group (P = .003, P < .0001, respectively). Although IL-1β levels were not statistically significant, they were higher in the CHB group compared to the controls (P = .07).
The results of our study showed that serum levels of TNF-α and IL-6 are increased in CHB patients.
本研究旨在评估慢性乙型肝炎病毒（HBV）感染患者的肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β和 IL-6 的血清水平。
本研究为单中心、前瞻性、随机对照试验。纳入 20 名健康志愿者和 30 名 HBeAg 阴性、计划行肝活检且未经治疗的慢性乙型肝炎（CHB）患者。采用酶联免疫吸附试验（ELISA）检测 CHB 患者和对照组血清中 TNF-α、IL-1β和 IL-6 的水平。采用曼-惠特尼 U 检验对结果进行统计学比较。
CHB 组（20 名男性，10 名女性）和对照组（10 名男性，10 名女性）的平均年龄分别为 33.3±9.7（17-55）和 26.1±12.3（16-57）。采用曼-惠特尼 U 检验比较两组时，发现 CHB 组 TNF-α 和 IL-6 水平明显高于对照组（P=0.003，P<0.0001）。尽管 IL-1β 水平无统计学意义，但 CHB 组高于对照组（P=0.07）。
本研究结果表明，CHB 患者血清 TNF-α 和 IL-6 水平升高。
