自噬与疾病的瞬间：过去与现在。
Moments in autophagy and disease: Past and present.
机构信息
Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Mol Aspects Med. 2021 Dec;82:100966. doi: 10.1016/j.mam.2021.100966. Epub 2021 Apr 28.
Abstract
Over the past several decades, research on autophagy, a highly conserved lysosomal degradation pathway, has been advanced by studies in different model organisms, especially in the field of its molecular mechanism and regulation. The malfunction of autophagy is linked to various diseases, among which cancer and neurodegenerative diseases are the major focus. In this review, we cover some other important diseases, including cardiovascular diseases, infectious and inflammatory diseases, and metabolic disorders, as well as rare diseases, with a hope of providing a more complete understanding of the spectrum of autophagy's role in human health.
摘要
在过去的几十年中，自噬（一种高度保守的溶酶体降解途径）的研究在不同的模式生物中得到了推进，特别是在其分子机制和调控方面。自噬的功能障碍与各种疾病有关，其中癌症和神经退行性疾病是主要关注点。在这篇综述中，我们涵盖了一些其他重要的疾病，包括心血管疾病、感染和炎症性疾病以及代谢紊乱，以及罕见疾病，希望能更全面地了解自噬在人类健康中的作用。
相似文献
1
Moments in autophagy and disease: Past and present.自噬与疾病的瞬间：过去与现在。
Mol Aspects Med. 2021 Dec;82:100966. doi: 10.1016/j.mam.2021.100966. Epub 2021 Apr 28.
2
Chemical Autophagy Regulators.化学自噬调节剂。
Adv Exp Med Biol. 2021;1208:289-309. doi: 10.1007/978-981-16-2830-6_13.
3
Autophagy and Human Neurodegenerative Diseases-A Fly's Perspective.自噬与人类神经退行性疾病——以果蝇为视角
Int J Mol Sci. 2017 Jul 23;18(7):1596. doi: 10.3390/ijms18071596.
4
Autophagy and human diseases.自噬与人类疾病。
Cell Res. 2014 Jan;24(1):69-79. doi: 10.1038/cr.2013.161. Epub 2013 Dec 10.
5
Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders.恢复神经退行性疾病中自噬和溶酶体功能的分子靶点和方法。
Mol Aspects Med. 2021 Dec;82:101018. doi: 10.1016/j.mam.2021.101018. Epub 2021 Sep 4.
6
Autophagy: renovation of cells and tissues.自噬：细胞和组织的更新。
Cell. 2011 Nov 11;147(4):728-41. doi: 10.1016/j.cell.2011.10.026.
7
Autophagy and Skin Diseases.自噬与皮肤疾病
Front Pharmacol. 2022 Feb 18;13:844756. doi: 10.3389/fphar.2022.844756. eCollection 2022.
8
Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases.溶酶体功能障碍与罕见神经退行性疾病中的自噬作用
J Mol Biol. 2020 Apr 3;432(8):2714-2734. doi: 10.1016/j.jmb.2020.02.033. Epub 2020 Mar 5.
9
The Autophagy Lysosomal Pathway and Neurodegeneration.自噬溶酶体途径与神经变性。
Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3):a033993. doi: 10.1101/cshperspect.a033993.
10
Autophagy and neuronal cell death in neurological disorders.自噬与神经退行性疾病中的神经元细胞死亡
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10):a008839. doi: 10.1101/cshperspect.a008839.
引用本文的文献
1
Chinese medicine monomers for hepatocellular carcinoma: New ideas related to autophagy.用于肝细胞癌的中药单体：与自噬相关的新思路
World J Gastroenterol. 2025 Jul 14;31(26):106113. doi: 10.3748/wjg.v31.i26.106113.
2
[ Formula suppresses airway inflammation in a rat model of asthmatic cold syndrome by regulating the HMGB1/Beclin-1 axis-mediated autophagy].[方剂通过调节HMGB1/Beclin-1轴介导的自噬抑制哮喘寒证大鼠模型气道炎症]
Nan Fang Yi Ke Da Xue Xue Bao. 2025 Jun 20;45(6):1153-1162. doi: 10.12122/j.issn.1673-4254.2025.06.05.
3
Autophagy and Its Association with Macrophages in Clonal Hematopoiesis Leading to Atherosclerosis.克隆性造血导致动脉粥样硬化过程中的自噬及其与巨噬细胞的关联
Int J Mol Sci. 2025 Apr 1;26(7):3252. doi: 10.3390/ijms26073252.
4
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy.间歇性禁食通过SIRT1介导的自噬改善大鼠七氟醚诱导的认知功能障碍。
Neurochem Res. 2025 Jan 20;50(1):81. doi: 10.1007/s11064-025-04335-9.
5
suppresses autophagic flux N6-methyladenosine demethylation of mRNA in acute pancreatitis.抑制急性胰腺炎中mRNA的自噬通量N6-甲基腺苷去甲基化。
World J Gastroenterol. 2024 Mar 28;30(12):1764-1776. doi: 10.3748/wjg.v30.i12.1764.
6
Dietary salt promotes cognition impairment through GLP-1R/mTOR/p70S6K signaling pathway.膳食盐通过 GLP-1R/mTOR/p70S6K 信号通路促进认知障碍。
Sci Rep. 2024 Apr 4;14(1):7970. doi: 10.1038/s41598-024-57998-9.
7
Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration.自噬调控生物材料：促进组织再生的多功能武器。
Cell Commun Signal. 2024 Feb 15;22(1):124. doi: 10.1186/s12964-023-01346-3.
8
Determination of Autophagy in Human Cervicovaginal Smears by Cytological and İmmunocytochemical Methods.通过细胞学和免疫细胞化学方法测定人宫颈阴道涂片中的自噬
J Cytol. 2023 Oct-Dec;40(4):177-183. doi: 10.4103/joc.joc_130_22. Epub 2023 Oct 16.
9
Autophagy Modulation and Its Implications on Glioblastoma Treatment.自噬调节及其对胶质母细胞瘤治疗的影响。
Curr Issues Mol Biol. 2023 Oct 29;45(11):8687-8703. doi: 10.3390/cimb45110546.
10
Topology and Function of the Autophagy Protein Atg15.自噬蛋白 Atg15 的拓扑结构和功能
Cells. 2023 Aug 12;12(16):2056. doi: 10.3390/cells12162056.
本文引用的文献
1
Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication.VPS34 和脂肪酸代谢抑制剂抑制 SARS-CoV-2 复制。
Cell Rep. 2021 Aug 3;36(5):109479. doi: 10.1016/j.celrep.2021.109479. Epub 2021 Jul 20.
2
Autophagy in tumour immunity and therapy.肿瘤免疫和治疗中的自噬作用。
Nat Rev Cancer. 2021 May;21(5):281-297. doi: 10.1038/s41568-021-00344-2. Epub 2021 Mar 23.
3
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).自噬监测分析方法使用和解释的指南（第 4 版）。
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8.
4
The case for open science: rare diseases.开放科学的案例：罕见病
JAMIA Open. 2020 Sep 11;3(3):472-486. doi: 10.1093/jamiaopen/ooaa030. eCollection 2020 Oct.
5
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.新型冠状病毒（SARS-CoV-2）的 ORF3a 阻断 HOPS 复合物介导的 SNARE 复合物组装，该复合物对于自噬溶酶体的形成是必需的。
Dev Cell. 2021 Feb 22;56(4):427-442.e5. doi: 10.1016/j.devcel.2020.12.010. Epub 2020 Dec 16.
6
An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer.自噬增强剂通过清除淀粉样寡聚体改善人胰岛淀粉样多肽转基因小鼠的糖尿病。
Nat Commun. 2021 Jan 8;12(1):183. doi: 10.1038/s41467-020-20454-z.
7
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance.介导线粒体自噬的脂肪炎症促进伴有肝胰岛素抵抗的 2 型糖尿病。
J Exp Med. 2021 Mar 1;218(3). doi: 10.1084/jem.20201416.
8
Cellular and physiological functions of C9ORF72 and implications for ALS/FTD.C9ORF72 的细胞和生理功能及其对 ALS/FTD 的影响。
J Neurochem. 2021 May;157(3):334-350. doi: 10.1111/jnc.15255. Epub 2020 Dec 18.
9
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?抗击 COVID-19 亮点：自噬在 SARS-CoV-2 感染中发挥作用？
Autophagy. 2020 Dec;16(12):2123-2127. doi: 10.1080/15548627.2020.1844940. Epub 2020 Nov 5.
10
Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world.氯喹衍生物在新型冠状病毒肺炎感染中的临床疗效：大数据与真实世界的比较荟萃分析
New Microbes New Infect. 2020 Jun 6;38:100709. doi: 10.1016/j.nmni.2020.100709. eCollection 2020 Nov.
Zotero 插件