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基于证据的护理干预对急性脑梗死患者神经功能和血清炎症因子的影响:一项随机对照试验。

Effects of an evidence-based nursing intervention on neurological function and serum inflammatory cytokines in patients with acute cerebral infarction: A randomized controlled trial.

机构信息

Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Party Office, Cangzhou Central Hospital, Cangzhou, Hebei, China.

出版信息

Restor Neurol Neurosci. 2021;39(2):129-137. doi: 10.3233/RNN-201080.

DOI:10.3233/RNN-201080
PMID:33935121
Abstract

BACKGROUND

Acute cerebral infarction is a clinically common and critical disease which seriously endangers the life and safety of elderly patients. Evidence-based nursing is an effective way of nursing and has great significance in improving the neurological function and quality of life of patients. In China, evidence-based nursing has been highlighted and highly developed in recent decades.

OBJECTIVES

This research aimed to investigate the effect of evidence-based nursing on the recovery of neurological function and serum inflammatory cytokines in patients with acute cerebral infarction.

METHODS

A total of 116 patients with acute cerebral infarction were randomly divided into two groups: the control group patients (n = 58) received conventional nursing, while the intervention group patients (n = 58) received evidence-based nursing intervention. National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer assessment (FMA) and activities of daily living (ADL) scores, as well as serum TNF-α and IL-6 levels were evaluated and compared between the two groups.

RESULTS

NIHSS scores in the intervention group were significantly lower than the control group. FMA and ADL scores in the intervention group were significantly higher than the control group. TNF-α and IL-6 levels in the serum of the intervention group were significantly lower than the control group.

CONCLUSIONS

In conclusion, evidence-based nursing has a positive effect on the treatment of patients with acute cerebral infarction, which decreases the level of serum inflammatory cytokines and contributes to the recovery of neurological function, motor function and activities of daily living.

摘要

背景

急性脑梗死是临床常见的危急重症,严重威胁老年患者的生命安全。循证护理是一种有效的护理方式,对改善患者的神经功能和生活质量具有重要意义。在中国,循证护理近几十年来得到了重视和大力发展。

目的

本研究旨在探讨循证护理对急性脑梗死患者神经功能恢复和血清炎症因子的影响。

方法

将 116 例急性脑梗死患者随机分为两组,对照组(n=58)患者接受常规护理,观察组(n=58)患者接受循证护理干预。评估并比较两组患者的美国国立卫生研究院卒中量表(NIHSS)评分、Fugl-Meyer 评估(FMA)评分和日常生活活动(ADL)评分,以及血清 TNF-α 和 IL-6 水平。

结果

观察组 NIHSS 评分明显低于对照组,FMA 评分和 ADL 评分明显高于对照组,血清 TNF-α 和 IL-6 水平明显低于对照组。

结论

综上所述,循证护理对急性脑梗死患者的治疗具有积极作用,可降低血清炎症因子水平,有助于神经功能、运动功能和日常生活活动的恢复。

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