Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro.
Department for Medical Biochemistry, University of Belgrade-Faculty of Pharmacy, Belgrade, Serbia.
Oxid Med Cell Longev. 2021 Jan 27;2021:6661940. doi: 10.1155/2021/6661940. eCollection 2021.
Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these markers, since to our knowledge, there are no studies that investigated that issue. A total of 292 participants underwent anthropometric measurements and venipuncture procedure for cardiometabolic risk factors assessment. Waist-to-height ratio (WHtR), body mass index, visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. Principal component analysis (PCA) grouped various cardiometabolic risk parameters into different factors. This analysis was used in the subsequent binary logistic regression analysis to estimate the predictive potency of the factors towards the highest PAB and tSHG values. Our results show that triglycerides, VAI, and LAP were positively and high density lipoprotein cholesterol (HDL-c) were negatively correlated with tSHG levels and vice versa with PAB/tSHG index, respectively. On the contrary, there were no independent correlations between each cardiometabolic risk factor and PAB. PCA revealed that obesity-renal function-related factor (i.e., higher WHtR, but lower urea and creatinine) predicts both high PAB (OR = 1.617, 95% CI (1.204-2.171), < 0.01) and low tSHG values (OR = 0.443, 95% CI (0.317-0.618), < 0.001), while obesity-dyslipidemia-related factor (i.e., lower HDL-c and higher triglycerides, VAI, and LAP) predicts high tSHG values (OR = 2.433, 95% CI (1.660-3.566), < 0.001). In conclusion, unfavorable cardiometabolic profile was associated with higher tSHG values. Further studies are needed to examine whether increased antioxidative capacity might be regarded as a compensatory mechanism due to free radicals' harmful effects.
不同的氧化应激产物并不总是与心脏代谢风险有关，因为到目前为止，报告的结果存在争议。本研究的目的是检查促氧化剂决定因素（促氧化剂-抗氧化剂平衡（PAB））和抗氧化防御能力的标志物（总巯基基团（tSHG）），以及它们在成年人群中心血管代谢危险因素中的比值（PAB/tSHG）。此外，我们旨在检查各种心脏代谢参数对这些标志物的联合影响，因为据我们所知，尚无研究调查过这个问题。共有 292 名参与者接受了人体测量测量和静脉穿刺程序，以评估心脏代谢危险因素。计算了腰高比（WHtR）、体重指数、内脏脂肪指数（VAI）和脂质蓄积产物（LAP）。主成分分析（PCA）将各种心脏代谢危险因素分为不同的因素。然后，将该分析用于随后的二元逻辑回归分析，以估计这些因素对 PAB 和 tSHG 值最高值的预测能力。我们的结果表明，甘油三酯、VAI 和 LAP 与 tSHG 水平呈正相关，高密度脂蛋白胆固醇（HDL-c）呈负相关，而 PAB/tSHG 指数则相反。相反，每个心脏代谢危险因素与 PAB 之间没有独立的相关性。PCA 显示，肥胖-肾功能相关因素（即较高的 WHtR，但较低的尿素和肌酐）预测 PAB 高（OR = 1.617，95%CI（1.204-2.171）， < 0.01）和 tSHG 值低（OR = 0.443，95%CI（0.317-0.618）， < 0.001），而肥胖-血脂异常相关因素（即 HDL-c 降低，甘油三酯、VAI 和 LAP 升高）预测 tSHG 值高（OR = 2.433，95%CI（1.660-3.566）， < 0.001）。总之，不利的心脏代谢谱与较高的 tSHG 值有关。需要进一步的研究来检查增加的抗氧化能力是否可以被视为由于自由基的有害影响而产生的补偿机制。
