Yin Huijia, Wang Dongdong, Yan Ruifang, Jin Xingxing, Hu Ying, Zhai Zhansheng, Duan Jinhui, Zhang Jian, Wang Kaiyu, Han Dongming
Department of MR, The First Affiliated Hospital, Xinxiang Medical University, Weihui, China.
Department of Radiology, People's Hospital of Zhengzhou, Zhengzhou, China.
Front Oncol. 2021 Apr 15;11:640906. doi: 10.3389/fonc.2021.640906. eCollection 2021.
This study aims to evaluate and compare the diagnostic value of DKI and APT in prostate cancer (PCa), and their correlation with Gleason Score (GS).
DKI and APT imaging of 49 patients with PCa and 51 patients with benign prostatic hyperplasia (BPH) were collected and analyzed, respectively. According to the GS, the patients with PCa were divided into high-risk, intermediate-risk and low-risk groups. The mean kurtosis (MK), mean diffusion (MD) and magnetization transfer ratio asymmetry (MTRasym, 3.5 ppm) values among PCa, BPH, and different GS groups of PCa were compared and analyzed respectively. The diagnostic accuracy of each parameter was evaluated by using the receiver operating characteristic (ROC) curve. The correlation between each parameter and GS was analyzed by using Spearman's rank correlation.
The MK and MTRasym (3.5 ppm) values were significantly higher in PCa group than in BPH group, while the MD value was significantly lower than in BPH group. The differences of MK/MD/MTRasym (3.5 ppm) between any two of the low-risk, intermediate-risk, and high-risk groups were all statistically significant (p <0.05). The MK value showed the highest diagnostic accuracy in differentiating PCa and BPH, BPH and low-risk, low-risk and intermediate-risk, intermediate-risk and high-risk (AUC = 0.965, 0.882, 0.839, 0.836). The MK/MD/MTRasym (3.ppm) values showed good and moderate correlation with GS ( = 0.844, -0.811, 0.640, p <0.05), respectively.
DKI and APT imaging are valuable in the diagnosis of PCa and demonstrate strong correlation with GS, which has great significance in the risk assessment of PCa.
本研究旨在评估和比较扩散峰度成像（DKI）和酰胺质子转移（APT）成像在前列腺癌（PCa）中的诊断价值，以及它们与 Gleason 评分（GS）的相关性。
分别收集并分析了 49 例 PCa 患者和 51 例良性前列腺增生（BPH）患者的 DKI 和 APT 影像。根据 GS，将 PCa 患者分为高风险、中风险和低风险组。分别比较和分析了 PCa、BPH 以及 PCa 不同 GS 组之间的平均峰度（MK）、平均扩散率（MD）和磁化转移率不对称性（MTRasym，3.5 ppm）值。使用受试者工作特征（ROC）曲线评估各参数的诊断准确性。采用 Spearman 等级相关性分析各参数与 GS 之间的相关性。
PCa 组的 MK 和 MTRasym（3.5 ppm）值显著高于 BPH 组，而 MD 值显著低于 BPH 组。低风险、中风险和高风险组中任意两组之间的 MK/MD/MTRasym（3.5 ppm）差异均具有统计学意义（p <0.05）。MK 值在鉴别 PCa 和 BPH、BPH 和低风险、低风险和中风险、中风险和高风险方面显示出最高的诊断准确性（AUC = 0.965、0.882、0.839、0.836）。MK/MD/MTRasym（3.ppm）值与 GS 分别显示出良好和中等程度的相关性（= 0.844、-0.811、0.640，p <0.05）。
DKI 和 APT 成像在 PCa 的诊断中具有重要价值，并且与 GS 显示出强相关性，这在 PCa 的风险评估中具有重要意义。
