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负载光/化疗药物的白细胞/血小板杂化膜伪装的树枝状大孔介孔二氧化硅纳米粒子用于三阴性乳腺癌联合治疗

Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment.

作者信息

Zhang Tao, Liu Hui, Li Ling, Guo Zhaoyang, Song Jia, Yang Xiaoying, Wan Guoyun, Li Rongshan, Wang Yinsong

机构信息

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmaceutics, School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.

The Key Laboratory of Biomedical Material, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, China.

出版信息

Bioact Mater. 2021 Apr 13;6(11):3865-3878. doi: 10.1016/j.bioactmat.2021.04.004. eCollection 2021 Nov.

DOI:10.1016/j.bioactmat.2021.04.004
PMID:33937590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8076651/
Abstract

Triple-negative breast cancer (TNBC) is an aggressive subset of breast cancer and currently lacks effective therapeutic targets. As two main phototherapeutic methods, photothermal therapy (PTT) and photodynamic therapy (PDT) show many advantages in TNBC treatment, and their combination with chemotherapy can achieve synergistic therapeutic effects. In the present study, a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane (LPHM) and dendritic large pore mesoporous silicon nanoparticles (DLMSNs). A near infrared (NIR) fluorescent dye IR780 and a chemotherapeutic drug doxorubicin (DOX) were co-loaded into the large pores of DLMSNs to prepare DLMSN@DOX/IR780 (DDI) nanoparticles (NPs), followed by camouflage with LPHM to obtain LPHM@DDI NPs. Through the mediation of LPHM, LPHM@DDI NPs showed an excellent TNBC-targeting ability and very high PTT/PDT performances and . Upon NIR laser irradiation, LPHM@DDI NPs exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells, and effectively suppressed tumor growth and recurrence in TNBC mice through tumor ablation and anti-angiogenesis. These synergistic effects were sourced from the combination of PTT/PDT and chemotherapy. Altogether, this study offers a promising biomimetic nanoplatform for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment.

摘要

三阴性乳腺癌（TNBC）是乳腺癌中侵袭性较强的一个亚型，目前缺乏有效的治疗靶点。作为两种主要的光疗方法，光热疗法（PTT）和光动力疗法（PDT）在TNBC治疗中显示出许多优势，并且它们与化疗联合可实现协同治疗效果。在本研究中，基于白细胞/血小板混合膜（LPHM）和树枝状大孔介孔硅纳米颗粒（DLMSNs）构建了一种仿生纳米平台。将近红外（NIR）荧光染料IR780和化疗药物阿霉素（DOX）共载入DLMSNs的大孔中，制备出DLMSN@DOX/IR780（DDI）纳米颗粒（NPs），随后用LPHM进行伪装，得到LPHM@DDI NPs。通过LPHM的介导，LPHM@DDI NPs表现出优异的TNBC靶向能力以及非常高的PTT/PDT性能。在近红外激光照射下，LPHM@DDI NPs在TNBC细胞中表现出协同细胞毒性和诱导凋亡活性，并通过肿瘤消融和抗血管生成有效抑制TNBC小鼠的肿瘤生长和复发。这些协同效应源于PTT/PDT与化疗的联合。总之，本研究为TNBC联合治疗的光/化疗药物高效共载和靶向递送提供了一种有前景的仿生纳米平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/eb48023549d6/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/eb48023549d6/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/ca95ee711880/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/fbaf95c7809f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/8723b993e274/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/8771f72feff2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/99ab9c4fc0a2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/18654d4f00e3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/35691d333f05/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/02ca4adfaf03/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/ab07bb9d9e7d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a4/8076651/eb48023549d6/gr9.jpg

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