Lo Eng H, Albers Gregory W, Dichgans Martin, Donnan Geoffrey, Esposito Elga, Foster Russell, Howells David W, Huang Yi-Ge, Ji Xunming, Klerman Elizabeth B, Lee Sarah, Li Wenlu, Liebeskind David S, Lizasoain Ignacio, Mandeville Emiri T, Moro Maria A, Ning MingMing, Ray David, Sakadžić Sava, Saver Jeffrey L, Scheer Frank A J L, Selim Magdy, Tiedt Steffen, Zhang Fang, Buchan Alastair M
CIRCA consortium (E.H.L., G.W.A., M.D., G.D., E.E., R.F., D.W.H., Y-G.H., X.J., E.B.K., S.L., W.L., D.S.L., I.L., E.T.M., M.A.M., M.N., D.R., S.S., J.L.S., F.A.J.L.S., M.S., S.T., F.Z., A.M.B.), Massachusetts General Hospital, Harvard Medical School, Boston.
Departments of Radiology (E.H.L., E.E., W.L., E.T.M., S.S., F.Z.), Massachusetts General Hospital, Harvard Medical School, Boston.
Stroke. 2021 Jun;52(6):2180-2190. doi: 10.1161/STROKEAHA.120.031742. Epub 2021 May 4.
Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.
昼夜节律生物学几乎调节着哺乳动物生理学、疾病及对治疗反应的方方面面。新出现的数据表明，昼夜节律生物学可能会显著影响中风的易感性、损伤、恢复机制以及对治疗的反应。在这篇综述/观点文章中，我们梳理了不断积累的文献，并尝试将昼夜节律生物学中的分子、细胞和生理途径与中风的临床后果联系起来。考虑到昼夜节律的复杂和多因素影响，可能会改善中风诊断和治疗的转化机会。
