Neuroscience, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Eur J Sport Sci. 2022 Aug;22(8):1296-1303. doi: 10.1080/17461391.2021.1922505. Epub 2021 Jun 28.
Studies have consistently reported a decreased level of brain-derived neurotrophic factor (BDNF) in individuals with Parkinson's disease (PD). The benefits of exercise on BDNF levels are well-documented in humans, however, the effects of acute exercise are inconclusive in neurological disorders. In addition, there are no studies investigating a precursor molecule - proBDNF - and its comparison to patients with vs. without depression or fatigue. Thirty patients with PD were instructed to walk on a treadmill at light to moderate intensity for 30 min. Generalized Estimating Equation (GEE) showed a significant effect of time (pre- vs. post-exercise) when compared individuals with vs. without depression [Wald Chi Square (4.392), p = 0.036)] and with vs. without fatigue [Wald Chi Square (7.123), p = 0.008)] for mature BDNF (mBDNF) level. There was no effect of group, time, and group x time interaction for proBDNF level when compared individuals with vs. without depression or fatigue. The present study showed that a single bout of light to moderate-intensity exercise increases mBDNF serum levels in patients with PD regardless of depression and fatigue. Our finding is important because it is necessary investigate methods to enhance the gains made by rehabilitation, especially when considering a short period of rehabilitation in different health services. The increase in mBDNF level can lead to an enhancement of neuroplasticity and facilitate the improvement of motor performance. No effect on proBDNF level could be explained, as this precursor molecule is cleaved by intracellular or extracellular enzymes.
研究一直报告帕金森病（PD）患者脑源性神经营养因子（BDNF）水平降低。运动对 BDNF 水平的益处已在人类中得到充分证明，然而，在神经障碍中，急性运动的影响尚无定论。此外，尚无研究调查前体分子 - proBDNF - 及其与有或无抑郁或疲劳的患者的比较。30 名 PD 患者被指示在跑步机上以轻到中度强度行走 30 分钟。广义估计方程（GEE）显示，与没有抑郁[沃尔德卡方（4.392），p = 0.036）]和没有疲劳[沃尔德卡方（7.123），p = 0.008）相比，时间（运动前后）对成熟 BDNF（mBDNF）水平的影响具有统计学意义）。与有或无抑郁或疲劳的患者相比，比较 proBDNF 水平时，组，时间和组 x 时间交互作用均无影响。本研究表明，单次轻到中度强度运动可增加 PD 患者的血清 mBDNF 水平，无论是否存在抑郁和疲劳。我们的发现很重要，因为有必要研究增强康复效果的方法，尤其是在考虑不同卫生服务机构的短期康复时。mBDNF 水平的增加可以导致神经可塑性增强，并促进运动性能的改善。由于这种前体分子被细胞内或细胞外酶切割，因此无法解释 proBDNF 水平没有变化。
