Queen Elizabeth University Hospital, Glasgow, UK.
Queen Elizabeth University Hospital, Glasgow, UK.
J Hosp Infect. 2021 Aug;114:111-116. doi: 10.1016/j.jhin.2021.04.028. Epub 2021 May 1.
Haemato-oncology patients are at increased risk of infection from atypical mycobacteria such as Mycobacterium chelonae which are commonly found in both domestic and hospital water systems.
To describe the investigation and control measures following two patient cases of M. chelonae and positive water samples in the study hospital.
Water testing was undertaken from outlets, storage tanks and mains supply. Whole-genome sequencing (WGS) was used to compare patient and positive water samples. The subsequent infection control measures implemented are described.
The WGS results showed two main populations of M. chelonae within the group of sampled isolates. The results showed that the patient strains were unrelated to each other, but that the isolate from one patient was closely related to environmental samples from water outlets, supporting nosocomial acquisition.
WGS was used to investigate two patient cases of M. chelonae and positive water samples from a hospital water supply. Relevant control measures and the potential for chemical dosing of water systems to enhance proliferation of atypical mycobacteria are discussed.
血液肿瘤患者感染非典型分枝杆菌（如脓肿分枝杆菌）的风险增加，而脓肿分枝杆菌通常存在于家庭和医院的供水系统中。
描述研究医院两例脓肿分枝杆菌患者和阳性水源水样后的调查和控制措施。
从出口、储水罐和主供水中进行水样检测。采用全基因组测序（WGS）比较患者和阳性水样样本。随后描述实施的感染控制措施。
WGS 结果显示，在采样分离株中存在两种主要的脓肿分枝杆菌种群。结果表明，患者菌株彼此无关，但其中一位患者的分离株与来自出水口的环境样本密切相关，支持医院获得性感染。
WGS 用于调查两例脓肿分枝杆菌患者和医院供水系统阳性水样。讨论了相关的控制措施以及向水系统投加化学物质以增强非典型分枝杆菌增殖的潜力。
