DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy.
DiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Piazza Sant'Eusebio 5, 13100 Vercelli, Italy.
Cells. 2021 Apr 30;10(5):1071. doi: 10.3390/cells10051071.
Intracellular Ca regulation plays a pivotal role in endothelial biology as well as during endothelial restoration processes. Interest in honey utilization in wound approaches is rising in recent years. In order to evaluate the positive effects of buckwheat honey on endothelial responses, we utilized an immortalized endothelial cell line to evaluate cellular responses upon honey exposure, with particular interest in Ca signaling involvement. The results highlight the positive effects of buckwheat honey on endothelial cells' responses and the central role played by Ca signaling as an encouraging target for more efficacious clinical treatments.
细胞内钙调节在血管内皮生物学以及内皮修复过程中起着关键作用。近年来,人们对蜂蜜在伤口处理中的应用越来越感兴趣。为了评估荞麦蜜对血管内皮反应的积极影响,我们利用永生化的内皮细胞系来评估蜂蜜暴露后细胞的反应,特别关注钙信号的参与。结果突出了荞麦蜜对内皮细胞反应的积极影响,以及钙信号作为更有效临床治疗的有希望靶点所发挥的核心作用。