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阿尔及利亚的皮肤利什曼病；姆西拉病灶概述

Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M'Sila.

作者信息

Beniklef Razika, Aoun Karim, Boudrissa Karim, Ben Abid Meriem, Cherif Kamel, Aissi Wafa, Benrekta Souad, Boubidi Said C, Späth Gerald F, Bouratbine Aïda, Sereno Denis, Harrat Zoubir

机构信息

Laboratoire d'Eco-épidémiologie Parasitaire et Génétique des Populations, Route du Petit Staoueli, Institut Pasteur d'Algérie, Dely-Brahim 16047, Algeria.

Laboratoire de Recherche "Parasitologie Médicale, Biotechnologies et Biomolécules", LR 20-IPT-06, Institut Pasteur de Tunis, Université Tunis El Manar, 13, Pl Pasteur BP 74, Tunis 1002, Tunisia.

出版信息

Microorganisms. 2021 Apr 29;9(5):962. doi: 10.3390/microorganisms9050962.

DOI:10.3390/microorganisms9050962
PMID:33947003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8146893/
Abstract

Algeria ranks second after Afghanistan for the incidence of cutaneous leishmaniasis (CL) worldwide. Here, we report a 34-years retrospective analysis of CL in Algeria and focused on the most affected region, the M'Sila province. All 66 cutaneous isolates corresponded to (.) . Our study of the sandfly and rodent fauna further highlighted the high density of and additional phlebotomine species of medical importance, not previously identified in M'Sila. Wild rodents belonging to nine species were trapped in M'Sila, and and were found infected by . In addition, was isolated from two visceral leishmaniasis cases, one dog and its proven vectors (, , and ) inventoried during the survey. The high incidence of CL in the M'Sila province is likely a consequence of the increase in minimum temperatures recorded that constitutes suitable conditions for establishing a high endemicity and leads to an explosive rise in leishmaniases cases in this region. A thorough investigation of the underlying risk factors is urgently needed to detect new cases earlier. All these would improve the preparedness to fight the disease.

摘要

在全球范围内，阿尔及利亚的皮肤利什曼病（CL）发病率仅次于阿富汗，位居第二。在此，我们报告了对阿尔及利亚CL进行的一项为期34年的回顾性分析，并重点关注了受影响最严重的地区——姆西拉省。所有66株皮肤分离株均对应于（.）。我们对白蛉和啮齿动物群落的研究进一步凸显了姆西拉省此前未被发现的、具有重要医学意义的某种白蛉以及其他白蛉种类的高密度分布。在姆西拉捕获了属于9个物种的野生啮齿动物，并且发现[具体物种1]和[具体物种2]感染了[具体病原体]。此外，从两例内脏利什曼病病例中分离出了[具体病原体]，其中一例来自一只狗及其在调查期间清查的已证实的传播媒介（[具体媒介物种1]、[具体媒介物种2]和[具体媒介物种3]）。姆西拉省CL的高发病率可能是所记录的最低温度升高的结果，这构成了建立高流行率的适宜条件，并导致该地区利什曼病病例呈爆发式增长。迫切需要对潜在风险因素进行全面调查，以便更早地发现新病例。所有这些都将提高抗击该疾病的准备程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/78940c54e548/microorganisms-09-00962-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/98c309e154e1/microorganisms-09-00962-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/cc8c0570461a/microorganisms-09-00962-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/bd266e9ac422/microorganisms-09-00962-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/f22de1b4b396/microorganisms-09-00962-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/4e837f27424d/microorganisms-09-00962-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/ca8c9a052352/microorganisms-09-00962-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/62270e1474e6/microorganisms-09-00962-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/3e045994221e/microorganisms-09-00962-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/6d52e62804fe/microorganisms-09-00962-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/78940c54e548/microorganisms-09-00962-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/98c309e154e1/microorganisms-09-00962-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/cc8c0570461a/microorganisms-09-00962-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/bd266e9ac422/microorganisms-09-00962-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/f22de1b4b396/microorganisms-09-00962-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/4e837f27424d/microorganisms-09-00962-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/ca8c9a052352/microorganisms-09-00962-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/62270e1474e6/microorganisms-09-00962-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/3e045994221e/microorganisms-09-00962-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/6d52e62804fe/microorganisms-09-00962-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d0/8146893/78940c54e548/microorganisms-09-00962-g010.jpg

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