Kaplan G A, Salonen J T, Cohen R D, Brand R J, Syme S L, Puska P
Human Population Laboratory, California Department of Health Services, Berkeley 94704.
Am J Epidemiol. 1988 Aug;128(2):370-80. doi: 10.1093/oxfordjournals.aje.a114977.
The association between an a priori measure of social connections and five-year mortality from all causes, cardiovascular diseases (International Classification of Diseases, Eighth Revision (ICD-8) codes 390-458), and ischemic heart disease (ICD-8 codes 410-414) was studied in 13,301 men and women from eastern Finland who were first interviewed in 1972 or 1977. For men, there was a graded association between extent of social connections and mortality. In multivariate models with adjustment for age, smoking, serum cholesterol, mean weighted blood pressure, measures of prevalent illness, and other possible confounders, men who were in the two lowest quintiles of the social connections scale were at increased risk compared with those in the highest quintile (odds ratio (OR)all cause = 1.54, 95% confidence interval (CI) = 1.21-1.95; ORcardiovascular disease = 1.54, 95% CI = 1.11-2.13; ORischemic heart disease = 1.34, 95% CI = 0.94-1.90). No strong or consistent association was found for women. The association for men was modified by levels of blood pressure with the effect of low social connections greater at higher levels of blood pressure. In three separate analyses, there was no evidence for confounding or effect modification due to prevalent illness at baseline.
对来自芬兰东部的13301名男性和女性进行了研究，这些人于1972年或1977年首次接受访谈，研究了社会关系的先验测量与全因死亡率、心血管疾病（国际疾病分类第八版（ICD - 8）编码390 - 458）和缺血性心脏病（ICD - 8编码410 - 414）之间的关联。对于男性，社会关系程度与死亡率之间存在分级关联。在对年龄、吸烟、血清胆固醇、平均加权血压、常见疾病测量以及其他可能的混杂因素进行调整的多变量模型中，社会关系量表处于最低两个五分位数的男性与处于最高五分位数的男性相比，风险增加（全因比值比（OR）= 1.54，95%置信区间（CI）= 1.21 - 1.95；心血管疾病OR = 1.54，95% CI = 1.11 - 2.13；缺血性心脏病OR = 1.34，95% CI = 0.94 - 1.90）。未发现女性有强烈或一致的关联。男性的这种关联因血压水平而改变，血压水平越高，社会关系低的影响越大。在三项单独分析中，没有证据表明基线时的常见疾病会造成混杂或效应修正。
