Pekkanen J, Tuomilehto J, Uutela A, Vartiainen E, Nissinen A
Department of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
BMJ. 1995 Sep 2;311(7005):589-93. doi: 10.1136/bmj.311.7005.589.
To evaluate the associations between social class as defined by occupation, health behaviour, and mortality from all causes and coronary heart disease among middle aged men and women in eastern Finland.
Prospective observational study of two independent, random population samples examined in 1972 and 1977.
North Karelia and Kuopio, Finland.
8967 men and 9694 women aged 30-64 years at the beginning of the follow up study. The subjects were followed up for mortality up till 1987 by using the National Death Registry.
Altogether 1429 men and 620 women died during the follow up, 603 men and 164 women of coronary heart disease. Among both sexes, compared with white collar workers unskilled blue collar workers had more adverse risk factors and also higher mortality due to coronary heart disease, other cardiovascular diseases, cancer, violent causes, and all other causes. Among men the age adjusted relative risk for all cause mortality in unskilled blue collar workers v white collar workers was reduced from 1.86 (95% confidence interval 1.55 to 2.22) to 1.47 (1.23 to 1.77) when adjusted for smoking, serum cholesterol concentration, hypertension, body mass index, and physical activity in leisure time. Among women the corresponding reduction in hazard ratio was from 1.49 (1.15 to 1.92) to 1.39 (1.07 to 1.81). The respective hazard ratios for coronary heart disease were 1.54 (1.16 to 2.02) and 1.22 (0.92 to 1.61) among men and 1.74 (1.05 to 2.90) and 1.66 (0.99 to 2.79) among women.
Unfavourable cardiovascular risk factors and high mortality are concentrated among lower social classes in Finland. Among men about half of the excess coronary and all cause mortality among unskilled blue collar workers was associated with their unfavourable risk factor profile. The association was smaller in women.
评估芬兰东部中年男性和女性中,由职业定义的社会阶层、健康行为与全因死亡率及冠心病死亡率之间的关联。
对1972年和1977年检测的两个独立随机人群样本进行前瞻性观察研究。
芬兰北卡累利阿和库奥皮奥。
随访研究开始时年龄在30 - 64岁之间的8967名男性和9694名女性。通过国家死亡登记处对研究对象进行随访直至1987年的死亡情况。
随访期间共有1429名男性和620名女性死亡,其中603名男性和164名女性死于冠心病。在两性中,与白领相比,非技术蓝领工人有更多不利的风险因素,且因冠心病、其他心血管疾病、癌症、暴力原因及所有其他原因导致死亡的风险也更高。在男性中,调整吸烟、血清胆固醇浓度、高血压、体重指数和休闲时间身体活动等因素后,非技术蓝领工人与白领相比,全因死亡率的年龄调整相对风险从1.86(95%置信区间1.55至2.22)降至1.47(1.23至1.77)。在女性中,相应的风险比降低从1.49(1.15至1.92)降至1.39(1.07至1.81)。男性冠心病的相应风险比分别为1.54(1.16至2.02)和1.22(0.92至1.61),女性分别为1.74(1.05至2.90)和1.66(0.99至2.79)。
在芬兰,不利的心血管风险因素和高死亡率集中在社会阶层较低的人群中。在男性中,非技术蓝领工人中冠心病和全因死亡率过高的情况约有一半与其不利的风险因素状况有关。女性中的这种关联较小。