SARS-CoV-2 和流感病毒导致急性呼吸窘迫综合征住院患儿的对比研究。
Comparative study of hospitalized children with acute respiratory distress syndrome caused by SARS-CoV-2 and influenza virus.
机构信息
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Thyroid and Breast Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
出版信息
BMC Infect Dis. 2021 May 4;21(1):412. doi: 10.1186/s12879-021-06068-w.
BACKGROUND
Since the outbreak of coronavirus disease 2019 in December 2019, more than 8 million cases have occurred worldwide as of June 16, 2020. However, it is important to distinguish COVID-19 from other respiratory infectious diseases, such as influenza. Here, we comparatively described the clinical characteristics of children with COVID-19 and paediatric patients with influenza.
METHODS
In this retrospective, single-centre study, we reviewed the electronic medical records of 585 paediatric patients with COVID-19 or influenza in Wuhan Children's Hospital, China. Clinical and epidemiological characteristics, laboratory findings, and clinical outcomes were comparatively analysed.
RESULTS
The median ages were 6.96 years (IQR, 2-10.81) for children with confirmed COVID-19, 2.67 years (IQR, 1.03-15.25) for those with influenza A and 3.67 years (IQR, 1.62-5.54) for those with influenza B. Fever was a symptom in 84 (34.7%) COVID-19 cases, 132 (70.21%) influenza A cases and 111 (74.50%) influenza B cases. The median length of stay (LOS) was 11 (8-15) days for paediatric COVID-19 patients, 4 (3-6) days for influenza A patients and 5 (3-6) days for influenza B patients. Twenty-six (13.98%) influenza A patients and 18 (12.59%) influenza B patients presented with decreased white blood cell counts, while 13 (5.33%) COVID-19 patients presented with decreased white blood cell counts. Eight (3.28%) COVID-19 patients, 23 (12.71%) influenza A patients and 21 (14.79%) influenza B patients experienced lymphocytopenia. Acute cardiac injury occurred in 18 (7.29%) COVID-19 patients, while 37 (19.68%) influenza A and 27 (18.12%) influenza B patients had acute cardiac injury.
CONCLUSION
In this study, the illnesses of children with COVID-19 were demonstrated to be less severe than those of paediatric patients with influenza, and COVID-19 patients had milder illness and fewer complications.
背景
自 2019 年 12 月新冠肺炎疫情爆发以来，截至 2020 年 6 月 16 日，全球已发生超过 800 万例病例。然而，重要的是要将 COVID-19 与流感等其他呼吸道传染病区分开来。在这里，我们比较描述了 COVID-19 患儿和儿科流感患者的临床特征。
方法
在这项回顾性、单中心研究中，我们回顾了中国武汉儿童医院 585 例 COVID-19 或流感患儿的电子病历。比较分析了临床和流行病学特征、实验室检查结果和临床转归。
结果
确诊 COVID-19 患儿的中位年龄为 6.96 岁（IQR，2-10.81），流感 A 患儿为 2.67 岁（IQR，1.03-15.25），流感 B 患儿为 3.67 岁（IQR，1.62-5.54）。发热是 84 例（34.7%）COVID-19 病例、132 例（70.21%）流感 A 病例和 111 例（74.50%）流感 B 病例的症状。儿科 COVID-19 患儿的中位住院时间（LOS）为 11 天（8-15 天），流感 A 患儿为 4 天（3-6 天），流感 B 患儿为 5 天（3-6 天）。26 例（13.98%）流感 A 患儿和 18 例（12.59%）流感 B 患儿白细胞计数减少，而 13 例（5.33%）COVID-19 患儿白细胞计数减少。8 例（3.28%）COVID-19 患儿、23 例（12.71%）流感 A 患儿和 21 例（14.79%）流感 B 患儿出现淋巴细胞减少症。18 例（7.29%）COVID-19 患儿发生急性心脏损伤，37 例（19.68%）流感 A 患儿和 27 例（18.12%）流感 B 患儿发生急性心脏损伤。
结论
在这项研究中，COVID-19 患儿的疾病表现出比流感患儿更轻，COVID-19 患儿的病情更轻，并发症更少。
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