Yoon Jee-Eun, Oh Dana, Hwang Inha, Park Jung Ah, Im Hee-Jin, Lee Seung Ku, Jung Ki-Young, Park Seong-Ho, Thomas Robert J, Shin Chol, Yun Chang-Ho
Department of Neurology, Uijeongbu Eulji Medical Center, Uijeongbu, Korea.
Department of Neurology, Seoul Medical Center, Seoul, Korea.
J Sleep Res. 2021 Dec;30(6):e13358. doi: 10.1111/jsr.13358. Epub 2021 May 5.
The fine structure of sleep electrocortical activity reflects health and disease. The current study provides normative data for sleep structure and electroencephalography (EEG) spectral power measures derived from overnight polysomnography (PSG) and examines the effect of age and sex among Korean middle-aged and older adults with or without obstructive sleep apnea (OSA). We analysed home PSG data from 1,153 adult participants of an ongoing population-based cohort study, the Korean Genome and Epidemiology Study. Sleep stages were visually scored and spectral power was measured on a single-channel EEG (C4-A1). We computed spectral power for five frequency ranges. The EEG power was reported in relative (%) and log-transformed absolute values (µV ). With ageing, the proportion of N1 sleep increased, whereas N3 decreased, which is more noticeable in men than in women. The amount of N3 was relatively low in this cohort. With ageing, relative delta power decreased and alpha and sigma power increased for the whole sleep period, which was more pronounced during REM sleep in non-OSA. For men compared with women, relative theta power was lower during REM and sigma and beta were higher during N1 sleep. The differences of relative powers by age and sex in OSA were comparable to those in non-OSA. In a community-based Korean population, we present normative data of sleep structure and spectral power for middle-aged or older adults of a non-Caucasian ethnicity. The values varied with age and sex and were not influenced by sleep apnea.
睡眠脑电图活动的精细结构反映健康与疾病状况。本研究提供了源自整夜多导睡眠图（PSG）的睡眠结构及脑电图（EEG）频谱功率测量的规范数据，并考察了韩国中老年有或无阻塞性睡眠呼吸暂停（OSA）的成年人中年龄和性别的影响。我们分析了来自一项正在进行的基于人群的队列研究——韩国基因组与流行病学研究的1153名成年参与者的家庭PSG数据。睡眠阶段通过视觉评分，频谱功率在单通道脑电图（C4 - A1）上进行测量。我们计算了五个频率范围的频谱功率。EEG功率以相对值（%）和对数转换后的绝对值（µV）报告。随着年龄增长，N1睡眠比例增加，而N3睡眠比例下降，男性比女性更明显。该队列中N3睡眠量相对较低。随着年龄增长，整个睡眠期的相对δ功率下降，α和σ功率增加，在非OSA的快速眼动（REM）睡眠期间更为明显。与女性相比，男性在REM睡眠期间的相对θ功率较低，在N1睡眠期间的相对σ和β功率较高。OSA患者中按年龄和性别划分的相对功率差异与非OSA患者相当。在一个以社区为基础的韩国人群中，我们给出了非白种人中老年人睡眠结构和频谱功率的规范数据。这些值随年龄和性别而变化，且不受睡眠呼吸暂停的影响。
