环丙沙星与广谱β-内酰胺类或氨基糖苷类药物对多重耐药嗜麦芽窄食单胞菌的协同相互作用。
Synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant Pseudomonas maltophilia.
作者信息
Chow A W, Wong J, Bartlett K H
机构信息
Department of Medicine, University of British Columbia, Vancouver, Canada.
出版信息
Antimicrob Agents Chemother. 1988 May;32(5):782-4. doi: 10.1128/AAC.32.5.782.
Abstract
The susceptibility of 28 clinical isolates of Pseudomonas maltophilia to 16 antimicrobial agents was determined in vitro by a standard agar dilution method with inoculum sizes of 10(4) and 10(6) CFU. All isolates exhibited multiple drug resistance. Nine isolates were selected for studies of combinations of ciprofloxacin with seven antipseudomonal beta-lactams and three aminoglycosides by a checkerboard agar dilution technique. Synergistic or additive combinations of ciprofloxacin in clinically achievable concentrations were most frequent with mezlocillin (89%), followed by cefoperazone (67%), piperacillin (56%), cefsulodin (56%), and ceftazidime (33%), and were infrequent with aztreonam (11%), the aminoglycosides (0 to 14%), or imipenem (0%). Antagonism was not observed in any combination. These data suggest that combinations of ciprofloxacin with these agents may be useful for some nosocomial multiply drug-resistant P. maltophilia infections.
摘要
采用标准琼脂稀释法，以10(4)和10(6)CFU的接种量，在体外测定了28株嗜麦芽窄食单胞菌临床分离株对16种抗菌药物的敏感性。所有分离株均表现出多重耐药性。通过棋盘琼脂稀释技术，选择9株分离株研究环丙沙星与7种抗假单胞菌β-内酰胺类药物和3种氨基糖苷类药物的联合用药情况。在临床可达到的浓度下，环丙沙星与美洛西林（89%）的协同或相加联合最为常见，其次是头孢哌酮（67%）、哌拉西林（56%）、头孢磺啶（56%）和头孢他啶（33%），与氨曲南（11%）、氨基糖苷类药物（0%至14%）或亚胺培南（0%）的联合则较少见。在任何联合用药中均未观察到拮抗作用。这些数据表明，环丙沙星与这些药物联合可能对某些医院内多重耐药嗜麦芽窄食单胞菌感染有用。
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