HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
AIDS Res Ther. 2021 May 5;18(1):28. doi: 10.1186/s12981-021-00335-1.
Coronavirus disease 2019 (COVID-19) was first detected in December 2019. In March 2020, the World Health Organization declared COVID-19 a pandemic. People with underlying medical conditions may be at greater risk of infection and experience complications from COVID-19. COVID-19 has the potential to affect People living with HIV (PLWH) in various ways, including be increased risk of COVID-19 acquisition and interruptions of HIV treatment and care. The purpose of this review article is to evaluate the impact of COVID-19 among PLWH. The contents focus on 4 topics: (1) the pathophysiology and host immune response of people infected with both SARS-CoV-2 and HIV, (2) present the clinical manifestations and treatment outcomes of persons with co-infection, (3) assess the impact of antiretroviral HIV drugs among PLWH infected with COVID-19 and (4) evaluate the impact of the COVID-19 pandemic on HIV services.
2019 年冠状病毒病(COVID-19)于 2019 年 12 月首次被发现。2020 年 3 月,世界卫生组织宣布 COVID-19 为大流行。患有基础疾病的人可能面临更大的感染风险,并出现 COVID-19 并发症。COVID-19 可能以多种方式影响艾滋病毒感染者(PLWH),包括增加感染 COVID-19 的风险和中断 HIV 治疗和护理。本文旨在评估 COVID-19 对 PLWH 的影响。本文内容集中在 4 个主题:(1)同时感染 SARS-CoV-2 和 HIV 的人的病理生理学和宿主免疫反应,(2)目前合并感染患者的临床表现和治疗结果,(3)评估抗逆转录病毒 HIV 药物对 COVID-19 感染 PLWH 的影响,(4)评估 COVID-19 大流行对 HIV 服务的影响。