Post-Graduate Program in Physiotherapy at Universidade Estadual Paulista - FCT/UNESP, Presidente Prudente, SP, Brazil.
Undergraduate Program in Physiotherapy and the Post-Graduate Program in Physiotherapy at Universidade Estadual Paulista - FCT/UNESP, Presidente Prudente, SP, Brazil.
Trials. 2021 May 5;22(1):326. doi: 10.1186/s13063-021-05285-7.
Due to its greater generation of muscle strength and less metabolic demand, eccentric exercise has been widely used in rehabilitation and for improving physical fitness. However, eccentric exercise can induce muscle damage by providing structural changes and reduced muscle function, so even with the protection caused by the repeated bout effect from eccentric exercise, it is necessary to seek alternatives to reduce this damage caused by stress. Thus, ischemic preconditioning could represent an aid to reduce the damage muscle or increase the protective effect caused by eccentric exercise.
To compare the effects of ischemic preconditioning, using different occlusion pressures, on acute and delayed responses to perceptual outcomes, markers of muscle damage, and performance in post-eccentric exercise recovery.
A randomized controlled placebo clinical trial will be carried out with 80 healthy men aged 18 to 35 years who will be randomly divided into four groups: ischemic preconditioning using total occlusion pressure, ischemic preconditoning with 40% more than total occlusion pressure, placebo (10 mmHg), and control. The ischemic preconditioning protocol will consist of four cycles of ischemia and reperfusion of five minutes each. All groups will perform an eccentric exercise protocol, and assessments will be carried out before, immediately after, and 24, 48, 72, and 96 h after the end of the eccentric exercise to evaluate creatine kinase, blood lactate, perception of recovery using the Likert scale, being sequentially evaluated, pain by the visual analog scale, pain threshold using a pressure algometer, muscle thickness by ultrasound, muscle tone, stiffness and elasticity by myotonometry, vectors of cell integrity through electrical bioimpedance, and maximal voluntary isometric contraction using the isokinetic dynamometer. The trial was registered at ClinicalTrials.gov (NCT04420819).
The present study aims to present an alternative technique to reduce muscle damage caused by eccentric exercise, which is easy to apply and low cost. If the benefits are proven, ischemic preconditioning could be used in any clinical practice that aims to minimize the damage caused by exercise, presenting an advance in the prescription of eccentric exercise and directly impacting on the results of post-exercise recovery.
ClinicalTrials.gov NCT04420819 . Registered on 19 May 2020; Last update 24 March 2021.
由于其能产生更大的肌肉力量和较少的代谢需求，离心运动已被广泛应用于康复和改善身体素质。然而，离心运动通过提供结构变化和降低肌肉功能来诱导肌肉损伤，因此，即使有离心运动的重复回合效应带来的保护，也有必要寻找替代方法来减少这种应激引起的损伤。因此，缺血预处理可能代表一种减少肌肉损伤或增加离心运动保护性效应的辅助手段。
比较不同闭塞压力的缺血预处理对急性和延迟感知结果、肌肉损伤标志物和离心运动后恢复时的运动表现的影响。
将对 80 名年龄在 18 至 35 岁之间的健康男性进行一项随机对照安慰剂临床试验，将他们随机分为四组：使用完全闭塞压力的缺血预处理组、使用比完全闭塞压力多 40%的缺血预处理组、安慰剂（10mmHg）组和对照组。缺血预处理方案将包括四个周期的缺血和再灌注，每个周期持续五分钟。所有组都将进行离心运动方案，评估将在离心运动结束前、立即后以及 24、48、72 和 96 小时后进行，以评估肌酸激酶、血乳酸、使用李克特量表评估恢复感知、疼痛视觉模拟评分、使用压力测痛计评估疼痛阈值、肌肉厚度超声、肌肉张力、硬度和弹性通过肌电仪、通过电阻抗生物电评估细胞完整性向量和使用等速测力计进行最大自主等长收缩。该试验在 ClinicalTrials.gov 注册（NCT04420819）。
本研究旨在提出一种减少离心运动引起的肌肉损伤的替代技术，该技术易于应用且成本低。如果证明有益，缺血预处理可以用于任何旨在最大限度减少运动引起的损伤的临床实践中，为离心运动的处方提供进展，并直接影响运动后的恢复效果。
ClinicalTrials.gov NCT04420819。注册于 2020 年 5 月 19 日；最后更新于 2021 年 3 月 24 日。
