Dowd Eilis, McKernan Declan P
Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway H91 TK33, Ireland.
Neuronal Signal. 2021 Apr 16;5(1):NS20200051. doi: 10.1042/NS20200051. eCollection 2021 Apr.
During the current coronavirus disease 2019 (COVID-19) pandemic, there has been noticeable increase in the reporting of neurological symptoms in patients. There is still uncertainty around the significance and long-term consequence of these symptoms. There are also many outstanding questions on whether the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) can directly infect the central nervous system (CNS). Given the long association between viral infections with neurodegenerative conditions such as Parkinson's disease (PD), it seems timely to review this literature again in the context of the COVID-19 pandemic and to glean some useful information from studies on similar viruses. In this commentary, we will consider the current knowledge on viral infections in the brain. In addition, we review the link between viral infection and neurodegeneration in PD, and review the recent literature on SARS infections, the potential link with PD and the potential areas of study in the future.
在当前2019年冠状病毒病（COVID-19）大流行期间，患者神经症状的报告明显增加。这些症状的重要性和长期后果仍不确定。关于致病病毒严重急性呼吸综合征冠状病毒2（SARS-CoV2）是否能直接感染中枢神经系统（CNS），也有许多悬而未决的问题。鉴于病毒感染与帕金森病（PD）等神经退行性疾病之间长期存在关联，在COVID-19大流行的背景下再次审视这一文献，并从对类似病毒的研究中收集一些有用信息似乎很及时。在这篇评论中，我们将考虑目前关于大脑中病毒感染的知识。此外，我们回顾了病毒感染与PD神经退行性变之间的联系，并回顾了最近关于SARS感染的文献、与PD的潜在联系以及未来潜在的研究领域。
