• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

复发性阿弗他口炎(RAS)作为吉尔伯特综合征患者罕见的口腔表现出现。

Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert's Syndrome.

作者信息

Heboyan Artak, Avetisyan Anna, Skallevold Hans Erling, Rokaya Dinesh, Marla Vinay, Vardanyan Anna

机构信息

Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University, Str. Koryun 2, Yerevan 0025, Armenia.

Department of Therapeutic Dentistry, Faculty of Stomatology, Yerevan State Medical University, Str. Koryun 2, Yerevan 0025, Armenia.

出版信息

Case Rep Dent. 2021 Apr 16;2021:6648729. doi: 10.1155/2021/6648729. eCollection 2021.

DOI:10.1155/2021/6648729
PMID:33953989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8068538/
Abstract

Recurrent aphthous stomatitis is an ulcerative disease of the oral cavity and can occur in isolation or as a manifestation of many systemic diseases. It is a quite common entity and may hence often be overlooked as an isolated lesion. Gilbert's syndrome is a genetic disorder where a deficiency of an enzyme associated with the conjugation of bilirubin results in unconjugated hyperbilirubinemia. The disease is generally asymptomatic and is aggravated by certain trigger factors. No associated oral manifestations are known. In this case report, we discuss the concomitant presence of recurrent aphthous stomatitis in a patient of Gilbert's syndrome. The presence of such recurrent stomatitis may represent as an oral manifestation of Gilbert's syndrome. Early identification of these entities may improve the overall quality of life of the patient.

摘要

复发性阿弗他口炎是一种口腔溃疡性疾病,可单独发生或作为许多全身性疾病的一种表现。它是一种相当常见的病症,因此常被忽视作为一种孤立的病变。吉尔伯特综合征是一种遗传性疾病,与胆红素结合相关的一种酶缺乏导致非结合性高胆红素血症。该疾病通常无症状,并因某些触发因素而加重。目前尚无相关口腔表现的报道。在本病例报告中,我们讨论了一名吉尔伯特综合征患者同时存在复发性阿弗他口炎的情况。这种复发性口炎的存在可能代表吉尔伯特综合征的一种口腔表现。早期识别这些病症可能会改善患者的整体生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/eee2a3738c96/CRID2021-6648729.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/698115745678/CRID2021-6648729.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/dd74c4d4d8b0/CRID2021-6648729.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/eee2a3738c96/CRID2021-6648729.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/698115745678/CRID2021-6648729.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/dd74c4d4d8b0/CRID2021-6648729.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8d/8068538/eee2a3738c96/CRID2021-6648729.003.jpg

相似文献

1
Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert's Syndrome.复发性阿弗他口炎(RAS)作为吉尔伯特综合征患者罕见的口腔表现出现。
Case Rep Dent. 2021 Apr 16;2021:6648729. doi: 10.1155/2021/6648729. eCollection 2021.
2
Genetic interactions in the pathogenesis of neonatal hyperbilirubinemia: Gilbert's Syndrome and glucose-6-phosphate dehydrogenase deficiency.新生儿高胆红素血症发病机制中的基因相互作用:吉尔伯特综合征与葡萄糖-6-磷酸脱氢酶缺乏症
J Perinatol. 2001 Dec;21 Suppl 1:S30-4; discussion S35-9. doi: 10.1038/sj.jp.7210630.
3
Molecular pathology of Crigler-Najjar type I and II and Gilbert's syndromes.Ⅰ型和Ⅱ型克里格勒-纳贾尔综合征及吉尔伯特综合征的分子病理学
Haematologica. 1999 Feb;84(2):150-7.
4
Gilbert's syndrome--a frequent cause of unconjugated hyperbilirubinemia in children after orthotopic liver transplantation.吉尔伯特综合征——儿童原位肝移植后非结合胆红素血症的常见病因。
Pediatr Transplant. 2012 Mar;16(2):201-4. doi: 10.1111/j.1399-3046.2012.01662.x.
5
Relationships between serum bilirubins and production and conjugation of bilirubin. Studies in Gilbert's syndrome, Crigler-Najjar disease, hemolytic disorders, and rat models.血清胆红素与胆红素生成及结合之间的关系。吉尔伯特综合征、克里格勒 - 纳贾尔病、溶血性疾病及大鼠模型的研究。
Gastroenterology. 1987 Feb;92(2):309-17. doi: 10.1016/0016-5085(87)90123-5.
6
Tyrosine kinase inhibitor resistance: a case report on chronic myeloid leukemia and Gilbert's syndrome.酪氨酸激酶抑制剂耐药:一例慢性髓性白血病合并吉尔伯特综合征的病例报告
AME Case Rep. 2021 Jan 25;5:1. doi: 10.21037/acr-20-107. eCollection 2021.
7
Gilbert's syndrome in a patient with predominantly negative symptoms of schizophrenia.吉尔伯特综合征合并以阴性症状为主的精神分裂症患者
Int J Psychiatry Clin Pract. 2007;11(3):239-41. doi: 10.1080/13651500600811735.
8
Gilbert's syndrome: diagnosis by typical serum bilirubin pattern.吉尔伯特综合征:通过典型血清胆红素模式进行诊断。
Clin Chim Acta. 1986 Jan 15;154(1):41-7. doi: 10.1016/0009-8981(86)90086-0.
9
Unusual Gilbert's syndrome genotype in a Greek patient suffering from both Gilbert's syndrome and familial mediterranean fever. A case report.一名同时患有吉尔伯特综合征和家族性地中海热的希腊患者的罕见吉尔伯特综合征基因型。病例报告。
Minerva Pediatr. 2008 Aug;60(4):469-72.
10
[Gilbert's jaundice. Current clinico-nosographic physiopathological and therapeutical aspects. I. Recent findings in Gilbert's syndrome].[吉尔伯特黄疸。当前临床诊断、生理病理及治疗方面。I. 吉尔伯特综合征的最新研究发现]
Minerva Med. 1976 Jul 21;67(35):2253-65.

引用本文的文献

1
Lessons Learned from Liver-on-Chip Platform.从芯片上肝脏平台获得的经验教训。
Ann Biomed Eng. 2025 Jun 28. doi: 10.1007/s10439-025-03779-y.
2
Topical Licorice for Aphthous: A Systematic Review of Clinical Trials.局部用甘草治疗口腔溃疡:临床试验的系统评价。
Iran J Med Sci. 2023 Sep;48(5):437-447. doi: 10.30476/IJMS.2022.94467.2576.
3
Exploring animal models in oral cancer research and clinical intervention: A critical review.探讨口腔癌研究和临床干预中的动物模型:批判性评价。

本文引用的文献

1
Recurrent Aphthous Stomatitis.复发性阿弗他口炎。
Actas Dermosifiliogr (Engl Ed). 2020 Jul-Aug;111(6):471-480. doi: 10.1016/j.ad.2019.09.004. Epub 2020 May 22.
2
Essentials of recurrent aphthous stomatitis.复发性阿弗他口炎要点
Biomed Rep. 2019 Aug;11(2):47-50. doi: 10.3892/br.2019.1221. Epub 2019 Jun 11.
3
The frequency, clinical course, and health related quality of life in adults with Gilbert's syndrome: a longitudinal study.吉尔伯特综合征成人患者的发病率、临床病程及健康相关生活质量:一项纵向研究。
Vet Med Sci. 2023 Jul;9(4):1833-1847. doi: 10.1002/vms3.1161. Epub 2023 May 17.
4
Current Infections of the Orofacial Region: Treatment, Diagnosis, and Epidemiology.口腔面部区域的当前感染:治疗、诊断与流行病学
Life (Basel). 2023 Jan 18;13(2):269. doi: 10.3390/life13020269.
5
Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.颅面再生医学中的合成材料:全面综述。
Front Bioeng Biotechnol. 2022 Nov 9;10:987195. doi: 10.3389/fbioe.2022.987195. eCollection 2022.
6
Clinical relevance of the use of Dentoxol for oral mucositis induced by radiotherapy: A phase II clinical trial.Dentoxol用于放疗引起的口腔黏膜炎的临床相关性:一项II期临床试验。
World J Clin Oncol. 2022 Oct 24;13(10):813-821. doi: 10.5306/wjco.v13.i10.813.
7
Assessment of Binary Agarose-Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization.评估双琼脂糖-卡波姆颊用凝胶的黏膜黏附药物传递性能:离体和体内特性研究。
Molecules. 2022 Oct 18;27(20):7004. doi: 10.3390/molecules27207004.
BMC Gastroenterol. 2019 Feb 4;19(1):22. doi: 10.1186/s12876-019-0931-2.
4
A Guide to Yellow Oral Mucosal Entities: Etiology and Pathology.黄色口腔黏膜病变指南:病因与病理学
Head Neck Pathol. 2019 Mar;13(1):33-46. doi: 10.1007/s12105-018-0977-4. Epub 2019 Jan 31.
5
Update on Neutrophil Function in Severe Inflammation.严重炎症中性粒细胞功能的最新研究进展。
Front Immunol. 2018 Oct 2;9:2171. doi: 10.3389/fimmu.2018.02171. eCollection 2018.
6
Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis.复发性阿弗他溃疡:病因、治疗及鉴别诊断的流行病学研究
An Bras Dermatol. 2018 Jun;93(3):341-346. doi: 10.1590/abd1806-4841.20186228.
7
Recurrent Aphthous Stomatitis: A Review.复发性阿弗他口炎:综述
J Clin Aesthet Dermatol. 2017 Mar;10(3):26-36. Epub 2017 Mar 1.
8
Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners.牙科医生复发性阿弗他口炎诊断与治疗指南
J Int Oral Health. 2015 May;7(5):74-80.
9
TLR2, TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis.复发性阿弗他口炎中TLR2、TLR4和CD86基因多态性
J Oral Pathol Med. 2015 Nov;44(10):857-63. doi: 10.1111/jop.12298. Epub 2014 Dec 8.
10
Recurrent aphthous stomatitis.复发性阿弗他口炎
Dent Clin North Am. 2014 Apr;58(2):281-97. doi: 10.1016/j.cden.2013.12.002. Epub 2014 Jan 21.