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经腹腔内注射蓖麻毒素自杀一例的教训。

Lessons from a suicide attempt by intra-abdominal ricin injection.

机构信息

Intensive Care Unit, Shamir Medical Center, Zerifin, Israel.

Pediatric Department, Shamir Medical Center, Zerifin, Israel.

出版信息

Am J Disaster Med. 2021;16(1):75-80. doi: 10.5055/ajdm.2021.0389.

DOI:10.5055/ajdm.2021.0389
PMID:33954978
Abstract

A 19-year-old woman was admitted to the emergency department 7 hours after a suicide attempt with an intra-abdominal injection of self-prepared ricin solution. In the following 6 days, she has developed multiorgan-failure, and despite all intensive care interventions-including plasma exchange, high-frequency ventilation, and continuous renal replacement -therapy-she passed away. We describe in detail the chain of events and discuss shortly the known literature about this rare poisoning.

摘要

一名 19 岁女性在尝试用自制蓖麻毒素溶液进行腹腔内注射自杀 7 小时后被收入急诊部。在接下来的 6 天里,她出现多器官衰竭,尽管进行了所有强化治疗干预措施,包括血浆置换、高频通气和持续肾脏替代治疗,但她还是去世了。我们详细描述了事件链,并简要讨论了关于这种罕见中毒的已知文献。

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Lessons from a suicide attempt by intra-abdominal ricin injection.经腹腔内注射蓖麻毒素自杀一例的教训。
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引用本文的文献

1
Parenteral Exposure of Mice to Ricin Toxin Induces Fatal Hypoglycemia by Cytokine-Mediated Suppression of Hepatic Glucose-6-Phosphatase Expression.小鼠经肠胃外途径暴露于蓖麻毒素后,通过细胞因子介导的肝葡萄糖-6-磷酸酶表达抑制导致致命性低血糖。
Toxins (Basel). 2022 Nov 23;14(12):820. doi: 10.3390/toxins14120820.
2
Distinct Metabolic States Are Observed in Hypoglycemia Induced in Mice by Ricin Toxin or by Fasting.在由蓖麻毒素或禁食引起的小鼠低血糖症中观察到不同的代谢状态。
Toxins (Basel). 2022 Nov 22;14(12):815. doi: 10.3390/toxins14120815.
3
Intramuscular Exposure to a Lethal Dose of Ricin Toxin Leads to Endothelial Glycocalyx Shedding and Microvascular Flow Abnormality in Mice and Swine.
肌肉内注射致死剂量的蓖麻毒素会导致小鼠和猪的血管内皮糖萼脱落和微血管血流异常。
Int J Mol Sci. 2021 Nov 16;22(22):12345. doi: 10.3390/ijms222212345.