Li Wenbo, Liu Dapeng, van Zijl Peter C M, Qin Qin
The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Magn Reson Med. 2021 Sep;86(3):1420-1433. doi: 10.1002/mrm.28815. Epub 2021 May 6.
To develop 3D MRI methods for cerebral blood volume (CBV) and venous cerebral blood volume (vCBV) estimation with whole-brain coverage using Fourier transform-based velocity-selective (FT-VS) pulse trains.
For CBV measurement, FT-VS saturation pulse trains were used to suppress static tissue, whereas CSF contamination was corrected voxel-by-voxel using a multi-readout acquisition and a fast CSF T scan. The vCBV mapping was achieved by inserting an arterial-nulling module that included a FT-VS inversion pulse train. Using these methods, CBV and vCBV maps were obtained on 6 healthy volunteers at 3 T.
The mean CBV and vCBV values in gray matter and white matter in different areas of the brain showed high correlation (r = 0.95 and P < .0001). The averaged CBV and vCBV values of the whole brain were 5.4 ± 0.6 mL/100 g and 2.5 ± 0.3 mL/100 g in gray matter, and 2.6 ± 0.5 mL/100 g and 1.5 ± 0.2 mL/100 g in white matter, respectively, comparable to the literature.
The feasibility of FT-VS-based CBV and vCBV estimation was demonstrated for 3D acquisition with large spatial coverage.
开发基于傅里叶变换的速度选择性（FT-VS）脉冲序列的全脑覆盖脑血容量（CBV）和静脉脑血容量（vCBV）估计的3D MRI方法。
对于CBV测量，使用FT-VS饱和脉冲序列抑制静态组织，而脑脊液污染通过多读出采集和快速脑脊液T扫描逐体素校正。通过插入包括FT-VS反转脉冲序列的动脉归零模块实现vCBV映射。使用这些方法，在6名3T的健康志愿者身上获得了CBV和vCBV图。
大脑不同区域灰质和白质中的平均CBV和vCBV值显示出高度相关性（r = 0.95，P <.0001）。全脑的平均CBV和vCBV值在灰质中分别为5.4±0.6 mL/100g和2.5±0.3 mL/100g，在白质中分别为2.6±0.5 mL/100g和1.5±0.2 mL/100g，与文献相当。
证明了基于FT-VS的CBV和vCBV估计用于大空间覆盖的3D采集的可行性。
