Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Ave, Ann Arbor, MI 48109-2216, USA.
Department of Biochemistry and Molecular Biology, Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Olivos 1007, Independencia, Santiago 8380492, Chile.
Cardiovasc Res. 2022 Mar 16;118(4):934-950. doi: 10.1093/cvr/cvab158.
Macroautophagy/autophagy is a conserved catabolic recycling pathway in which cytoplasmic components are sequestered, degraded, and recycled to survive various stress conditions. Autophagy dysregulation has been observed and linked with the development and progression of several pathologies, including cardiovascular diseases, the leading cause of death in the developed world. In this review, we aim to provide a broad understanding of the different molecular factors that govern autophagy regulation and how these mechanisms are involved in the development of specific cardiovascular pathologies, including ischemic and reperfusion injury, myocardial infarction, cardiac hypertrophy, cardiac remodelling, and heart failure.
自噬是一种保守的分解代谢循环途径，其中细胞质成分被隔离、降解并回收，以在各种应激条件下存活。自噬失调已被观察到，并与几种病理学的发展和进展有关，包括心血管疾病，这是发达国家的主要死亡原因。在这篇综述中，我们旨在提供对不同分子因素的广泛理解，这些因素控制自噬的调节，以及这些机制如何参与特定心血管病理学的发展，包括缺血再灌注损伤、心肌梗死、心肌肥厚、心脏重塑和心力衰竭。
