自噬在心血管病理学中的作用。
The role of autophagy in cardiovascular pathology.
机构信息
Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Ave, Ann Arbor, MI 48109-2216, USA.
Department of Biochemistry and Molecular Biology, Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Olivos 1007, Independencia, Santiago 8380492, Chile.
出版信息
Cardiovasc Res. 2022 Mar 16;118(4):934-950. doi: 10.1093/cvr/cvab158.
Abstract
Macroautophagy/autophagy is a conserved catabolic recycling pathway in which cytoplasmic components are sequestered, degraded, and recycled to survive various stress conditions. Autophagy dysregulation has been observed and linked with the development and progression of several pathologies, including cardiovascular diseases, the leading cause of death in the developed world. In this review, we aim to provide a broad understanding of the different molecular factors that govern autophagy regulation and how these mechanisms are involved in the development of specific cardiovascular pathologies, including ischemic and reperfusion injury, myocardial infarction, cardiac hypertrophy, cardiac remodelling, and heart failure.
摘要
自噬是一种保守的分解代谢循环途径，其中细胞质成分被隔离、降解并回收，以在各种应激条件下存活。自噬失调已被观察到，并与几种病理学的发展和进展有关，包括心血管疾病，这是发达国家的主要死亡原因。在这篇综述中，我们旨在提供对不同分子因素的广泛理解，这些因素控制自噬的调节，以及这些机制如何参与特定心血管病理学的发展，包括缺血再灌注损伤、心肌梗死、心肌肥厚、心脏重塑和心力衰竭。
相似文献
1
The role of autophagy in cardiovascular pathology.自噬在心血管病理学中的作用。
Cardiovasc Res. 2022 Mar 16;118(4):934-950. doi: 10.1093/cvr/cvab158.
2
Molecular mechanisms of autophagy in the cardiovascular system.心血管系统中自噬的分子机制。
Circ Res. 2015 Jan 30;116(3):456-67. doi: 10.1161/CIRCRESAHA.114.303788.
3
Autophagy during cardiac remodeling.心脏重塑过程中的自噬
J Mol Cell Cardiol. 2016 Jun;95:11-8. doi: 10.1016/j.yjmcc.2015.12.003. Epub 2015 Dec 8.
4
Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.自噬调节：一种治疗心肌肥厚的潜在方法。
Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H304-H319. doi: 10.1152/ajpheart.00145.2017. Epub 2017 Jun 2.
5
The role of autophagy in the heart.自噬在心脏中的作用。
Cell Death Differ. 2009 Jan;16(1):31-8. doi: 10.1038/cdd.2008.163. Epub 2008 Nov 14.
6
The role of autophagic degradation in the heart.自噬降解在心脏中的作用。
J Mol Cell Cardiol. 2015 Jan;78:73-9. doi: 10.1016/j.yjmcc.2014.09.029. Epub 2014 Oct 6.
7
Cardiovascular autophagy: concepts, controversies, and perspectives.心血管自噬：概念、争议与展望。
Autophagy. 2013 Oct;9(10):1455-66. doi: 10.4161/auto.25969. Epub 2013 Aug 14.
8
Therapeutic potentials of modulating autophagy in pathological cardiac hypertrophy.调控病理性心肌肥厚自噬的治疗潜力。
Biomed Pharmacother. 2022 Dec;156:113967. doi: 10.1016/j.biopha.2022.113967. Epub 2022 Nov 4.
9
The role of autophagic cell death in cardiac disease.自噬性细胞死亡在心脏疾病中的作用。
J Mol Cell Cardiol. 2022 Dec;173:16-24. doi: 10.1016/j.yjmcc.2022.08.362. Epub 2022 Sep 6.
10
miR-93 and synaptotagmin-7: two novel players in the regulation of autophagy during cardiac hypertrophy.miR-93 和突触结合蛋白 7：心肌肥厚过程中自噬调节的两个新的调控因子。
FEBS J. 2024 Feb;291(3):441-444. doi: 10.1111/febs.17008. Epub 2023 Dec 1.
引用本文的文献
1
Transcription factor ETV1 promotes angiogenesis after myocardial infarction via activation of the VEGFA/VEGFR2/eNOS pathway.转录因子ETV1通过激活VEGFA/VEGFR2/eNOS通路促进心肌梗死后的血管生成。
Front Cardiovasc Med. 2025 Aug 15;12:1633438. doi: 10.3389/fcvm.2025.1633438. eCollection 2025.
2
Crocetin Attenuates Fibroblast-to-Myofibroblast Transition after Myocardial Infarction in Mice by Regulating Autophagy.西红花酸通过调节自噬减轻小鼠心肌梗死后成纤维细胞向肌成纤维细胞的转变。
Cardiovasc Drugs Ther. 2025 Aug 22. doi: 10.1007/s10557-025-07758-2.
3
The Role of Autophagy in the Regulation of Bidirectional Relationships in Diabetic Periodontitis.自噬在糖尿病性牙周炎双向关系调节中的作用
J Inflamm Res. 2025 Jun 13;18:7781-7794. doi: 10.2147/JIR.S533791. eCollection 2025.
4
Advances in Targeted Autophagy Modulation Strategies to Treat Cancer and Associated Treatment-Induced Cardiotoxicity.治疗癌症及相关治疗诱导性心脏毒性的靶向自噬调节策略进展
Pharmaceuticals (Basel). 2025 May 1;18(5):671. doi: 10.3390/ph18050671.
5
Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy.内皮主穹窿蛋白通过促进帕金蛋白介导的线粒体自噬减轻血管重塑。
Nat Commun. 2025 May 10;16(1):4365. doi: 10.1038/s41467-025-59644-y.
6
tRF5-22-SerGCT-1 protects the heart against myocardial injury by targeting MSK1.tRF5-22-SerGCT-1通过靶向MSK1保护心脏免受心肌损伤。
Epigenomics. 2025 May;17(7):439-451. doi: 10.1080/17501911.2025.2495544. Epub 2025 Apr 23.
7
Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology.中药复方通过调节信号通路改善心脏相关病理状况。
Front Pharmacol. 2025 Apr 2;16:1499060. doi: 10.3389/fphar.2025.1499060. eCollection 2025.
8
The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a.肠道微生物群代谢产物氧化三甲胺通过激活肌浆网钙ATP酶2a的自噬降解促进心肌肥大。
Commun Biol. 2025 Apr 10;8(1):596. doi: 10.1038/s42003-025-08016-9.
9
The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection.内质网自噬受体FAM134B是鼠伤寒沙门氏菌的作用靶点，有助于感染。
Nat Commun. 2025 Mar 25;16(1):2923. doi: 10.1038/s41467-025-58035-7.
10
Neurodegenerative diseases and neuroinflammation-induced apoptosis.神经退行性疾病与神经炎症诱导的细胞凋亡。
Open Life Sci. 2025 Feb 25;20(1):20221051. doi: 10.1515/biol-2022-1051. eCollection 2025.
本文引用的文献
1
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.心肌基因表达特征在射血分数保留的心力衰竭患者中。
Circulation. 2021 Jan 12;143(2):120-134. doi: 10.1161/CIRCULATIONAHA.120.050498. Epub 2020 Oct 29.
2
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.ATG9A 的结构、脂质翻转活性及其在自噬体形成中的作用。
Nat Struct Mol Biol. 2020 Dec;27(12):1194-1201. doi: 10.1038/s41594-020-00520-2. Epub 2020 Oct 26.
3
Down-regulation of Beclin1 promotes direct cardiac reprogramming.Beclin1的下调促进直接心脏重编程。
Sci Transl Med. 2020 Oct 21;12(566). doi: 10.1126/scitranslmed.aay7856.
4
Fine-tuning of AMPK-ULK1-mTORC1 regulatory triangle is crucial for autophagy oscillation.微调 AMPK-ULK1-mTORC1 调节三角对自噬振荡至关重要。
Sci Rep. 2020 Oct 20;10(1):17803. doi: 10.1038/s41598-020-75030-8.
5
Defective Autophagy in Vascular Smooth Muscle Cells Alters Vascular Reactivity of the Mouse Femoral Artery.血管平滑肌细胞中自噬缺陷改变小鼠股动脉的血管反应性。
Front Physiol. 2020 Sep 23;11:548943. doi: 10.3389/fphys.2020.548943. eCollection 2020.
6
MMP9 inhibition increases autophagic flux in chronic heart failure.MMP9 抑制可增加慢性心力衰竭中的自噬通量。
Am J Physiol Heart Circ Physiol. 2020 Dec 1;319(6):H1414-H1437. doi: 10.1152/ajpheart.00032.2020. Epub 2020 Oct 16.
7
Microautophagy - distinct molecular mechanisms handle cargoes of many sizes.微自噬——不同的分子机制处理不同大小的货物。
J Cell Sci. 2020 Sep 9;133(17):jcs246322. doi: 10.1242/jcs.246322.
8
Ischemia induces autophagy of endothelial cells and stimulates angiogenic effects in a hindlimb ischemia mouse model.缺血诱导内皮细胞自噬，并在小鼠后肢缺血模型中刺激血管生成作用。
Cell Death Dis. 2020 Aug 14;11(8):624. doi: 10.1038/s41419-020-02849-4.
9
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.人类 ATG9A 的结构，核心自噬机器中唯一的跨膜蛋白。
Cell Rep. 2020 Jun 30;31(13):107837. doi: 10.1016/j.celrep.2020.107837.
10
Novel Dual-Fluorescent Mitophagy Reporter Reveals a Reduced Mitophagy Flux in Type 1 Diabetic Mouse Heart.新型双荧光自噬报告系统揭示 1 型糖尿病小鼠心脏自噬通量降低。
J Am Osteopath Assoc. 2020 Jul 1;120(7):446-455. doi: 10.7556/jaoa.2020.072.
Zotero 插件