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低钾血症的管理更新及心血管疾病患者更低血钾水平的目标:与欧洲心脏病学会心血管药物治疗工作组合作进行的综述

Update on management of hypokalaemia and goals for the lower potassium level in patients with cardiovascular disease: a review in collaboration with the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy.

作者信息

Krogager Maria Lukács, Kragholm Kristian, Thomassen Jesper Qvist, Søgaard Peter, Lewis Basil S, Wassmann Sven, Baumgartner Iris, Ceconi Claudio, Schmidt Thomas Andersen, Kaski Juan Carlos, Drexel Heinz, Semb Anne Grete, Agewall Stefan, Niessner Alexander, Savarese Gianluigi, Kjeldsen Keld Per, Borghi Claudio, Tamargo Juan, Torp-Pedersen Christian

机构信息

Department of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.

Department of Cardiology, Region Hospital North Jutland, Bispensgade 37, 9800, Hjørring, Denmark.

出版信息

Eur Heart J Cardiovasc Pharmacother. 2021 Nov 3;7(6):557-567. doi: 10.1093/ehjcvp/pvab038.

DOI:10.1093/ehjcvp/pvab038
PMID:33956964
Abstract

Hypokalaemia is common in patients with cardiovascular disease. In this review, we emphasize the importance of tight potassium regulation in patients with cardiovascular disease based on findings from observational studies. To enhance the understanding, we also describe the mechanisms of potassium homeostasis maintenance, the most common causes of hypokalaemia and present strategies for monitoring and management of low potassium levels. We propose elevation of potassium in asymptomatic patients with lower normal concentrations and concurrent cardiovascular disease. These proposals are intended to assist clinicians until more evidence is available.

摘要

低钾血症在心血管疾病患者中很常见。在本综述中,我们根据观察性研究的结果强调了心血管疾病患者严格钾调节的重要性。为了增进理解,我们还描述了钾稳态维持的机制、低钾血症最常见的原因,并介绍了低钾水平的监测和管理策略。我们建议对血钾浓度略低于正常范围且患有心血管疾病的无症状患者进行补钾。在获得更多证据之前,这些建议旨在帮助临床医生。

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