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Atrial Fibrillation and Ischemic Stroke With the Amyloidogenic V122I Transthyretin Variant Among Black Americans.

作者信息

Selvaraj Senthil, Claggett Brian, Minamisawa Masatoshi, Windham B Gwen, Chen Lin Y, Inciardi Riccardo M, Buxbaum Joel N, Mosley Thomas H, Shah Amil M, Solomon Scott D

出版信息

J Am Coll Cardiol. 2021 Jul 6;78(1):89-91. doi: 10.1016/j.jacc.2021.04.042. Epub 2021 May 3.

DOI:10.1016/j.jacc.2021.04.042
PMID:33957237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11391793/
Abstract
摘要

相似文献

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Atrial Fibrillation and Ischemic Stroke With the Amyloidogenic V122I Transthyretin Variant Among Black Americans.美国黑人中伴有淀粉样变V122I转甲状腺素蛋白变异体的心房颤动和缺血性卒中
J Am Coll Cardiol. 2021 Jul 6;78(1):89-91. doi: 10.1016/j.jacc.2021.04.042. Epub 2021 May 3.
2
Relation of clinical, echocardiographic and electrocardiographic features of cardiac amyloidosis to the presence of the transthyretin V122I allele in older African-American men.老年非裔美国男性心脏淀粉样变的临床、超声心动图和心电图特征与转甲状腺素蛋白 V122I 等位基因的关系。
Am J Cardiol. 2011 Aug 1;108(3):440-4. doi: 10.1016/j.amjcard.2011.03.069. Epub 2011 May 19.
3
The amyloidogenic V122I transthyretin variant in elderly black Americans.老年美国黑人中的淀粉样变V122I转甲状腺素蛋白变体
N Engl J Med. 2015 Jan 1;372(1):21-9. doi: 10.1056/NEJMoa1404852.
4
V122I transthyretin variant in elderly black Americans.美国老年黑人中的V122I转甲状腺素蛋白变体
N Engl J Med. 2015 Apr 30;372(18):1769. doi: 10.1056/NEJMc1503222.
5
V122I transthyretin variant in elderly black Americans.老年美国黑人中的V122I转甲状腺素蛋白变体
N Engl J Med. 2015 Apr 30;372(18):1768. doi: 10.1056/NEJMc1503222.
6
V122I transthyretin variant in elderly black Americans.老年美国黑人中的V122I转甲状腺素蛋白变体
N Engl J Med. 2015 Apr 30;372(18):1769. doi: 10.1056/NEJMc1503222.
7
Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry.V122I 遗传性转甲状腺素蛋白淀粉样变性基因突变与非洲裔或西班牙裔/拉丁裔个体心力衰竭的关联。
JAMA. 2019 Dec 10;322(22):2191-2202. doi: 10.1001/jama.2019.17935.
8
Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans.转甲状腺素蛋白 V122I(pV142I)*心脏淀粉样变性:一种与年龄相关的常染色体显性遗传性心肌病,在老年非裔美国人中因显著心脏病而被忽视的常见病因。
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Prevalence of the amyloidogenic transthyretin (TTR) V122I allele in 14 333 African-Americans.在 14333 名非裔美国人中,淀粉样变性转甲状腺素(TTR)V122I 等位基因的流行率。
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Cardiovascular Disease and Mortality in Black Women Carrying the Amyloidogenic V122I Transthyretin Gene Variant.携带有淀粉样变 V122I 转甲状腺素蛋白基因变异的黑人女性中的心血管疾病和死亡率。
JACC Heart Fail. 2023 Sep;11(9):1189-1199. doi: 10.1016/j.jchf.2023.02.003. Epub 2023 Mar 5.

引用本文的文献

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Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I Variant.淀粉样变p.V142I变异携带者一生中发生心力衰竭和心房颤动的风险
Circ Genom Precis Med. 2025 Jul 23:e004911. doi: 10.1161/CIRCGEN.124.004911.
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Prevalence of Atrial Fibrillation and Intervention Therapy in Cardiac Amyloidosis.心脏淀粉样变性中房颤的患病率及干预治疗
Rev Cardiovasc Med. 2025 May 22;26(5):37064. doi: 10.31083/RCM37064. eCollection 2025 May.
3
Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges.携带p.V142I变异的遗传性转甲状腺素蛋白心脏淀粉样变性:机制见解与诊断挑战
Circ Heart Fail. 2025 Jun;18(6):e012469. doi: 10.1161/CIRCHEARTFAILURE.124.012469. Epub 2025 Mar 14.
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Genotype- vs Phenotype-Guided Approaches to Improve ATTR Detection.改善转甲状腺素蛋白淀粉样变性检测的基因型与表型引导方法
JAMA Cardiol. 2024 Nov 1;9(11):957-959. doi: 10.1001/jamacardio.2024.2654.
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Arrhythmic Risk Stratification in Cardiac Amyloidosis: A Review of the Current Literature.心脏淀粉样变性中的心律失常风险分层:当前文献综述
J Cardiovasc Dev Dis. 2024 Jul 14;11(7):222. doi: 10.3390/jcdd11070222.
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Atrial amyloidosis: mechanisms and clinical manifestations.心房淀粉样变:机制与临床表现。
Eur J Heart Fail. 2022 Nov;24(11):2019-2028. doi: 10.1002/ejhf.2650. Epub 2022 Aug 21.
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Cerebral Ischemic Events: An Overlooked Complication of Transthyretin Cardiac Amyloidosis in Afro-Caribbean Patients.脑缺血事件:非洲加勒比裔患者转甲状腺素蛋白心脏淀粉样变被忽视的并发症
Front Neurol. 2022 May 19;13:878292. doi: 10.3389/fneur.2022.878292. eCollection 2022.
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Systemic embolism in amyloid transthyretin cardiomyopathy.淀粉样变性转甲状腺素蛋白心肌病中的系统性栓塞。
Eur J Heart Fail. 2022 Aug;24(8):1387-1396. doi: 10.1002/ejhf.2566. Epub 2022 Jul 11.
9
Toward Population-Based Genetic Screening for Hereditary Amyloidosis.迈向基于人群的遗传性淀粉样变性基因筛查。
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The left atrium in cardiac amyloidosis: a valuable but still underused observation window on the overall disease process.心脏淀粉样变中的左心房:对整体疾病进程而言是一个有价值但仍未充分利用的观察窗口。
Eur J Heart Fail. 2021 Aug;23(8):1296-1299. doi: 10.1002/ejhf.2257. Epub 2021 Jun 9.

本文引用的文献

1
Anticoagulation with warfarin compared to novel oral anticoagulants for atrial fibrillation in adults with transthyretin cardiac amyloidosis: comparison of thromboembolic events and major bleeding.比较伴有转甲状腺素蛋白心脏淀粉样变的成人心房颤动患者使用华法林与新型口服抗凝剂的抗凝治疗:血栓栓塞事件和大出血的比较。
Amyloid. 2021 Mar;28(1):30-34. doi: 10.1080/13506129.2020.1810010. Epub 2020 Aug 19.
2
Direct Current Cardioversion of Atrial Arrhythmias in Adults With Cardiac Amyloidosis.成人心脏淀粉样变伴心律失常的直流电复律。
J Am Coll Cardiol. 2019 Feb 12;73(5):589-597. doi: 10.1016/j.jacc.2018.10.079.
3
Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: atherosclerosis risk in communities-neurocognitive study.血管成像异常与认知:非痴呆个体中皮质体积的介导作用:社区动脉粥样硬化风险-神经认知研究
Stroke. 2015 Feb;46(2):433-40. doi: 10.1161/STROKEAHA.114.007847. Epub 2015 Jan 6.
4
The amyloidogenic V122I transthyretin variant in elderly black Americans.老年美国黑人中的淀粉样变V122I转甲状腺素蛋白变体
N Engl J Med. 2015 Jan 1;372(1):21-9. doi: 10.1056/NEJMoa1404852.