School of Pharmacy, Fudan University, Shanghai 201203, China.
State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Bioorg Chem. 2021 Jul;112:104916. doi: 10.1016/j.bioorg.2021.104916. Epub 2021 Apr 15.
Three unprecedented dimeric clerodane diterpenoids, dodovisdimers A-C (1-3), along with six known clerodane monomers (4-9), were isolated from Dodonaea viscosa. Compounds 1-3 may be biosynthetically formed via an intermolecular Diels-Alder [4+2] cycloaddition between the coexisting monomers 4-7. The structures of these clerodanes were characterized by spectroscopic techniques, X-ray crystallographic study, and ECD calculations. Some isolates exerted antiviral effects on human influenza A virus (H3N2) in vitro.
从黄鹌菜中分离得到了三种前所未有的二聚型裂环烯醚萜类化合物，即 dodovisdimers A-C（1-3），以及六种已知的裂环烯醚萜单体（4-9）。化合物 1-3 可能是通过共存单体 4-7 之间的分子间 Diels-Alder [4+2] 环加成反应生物合成的。这些裂环烯醚萜的结构通过光谱技术、X 射线晶体学研究和 ECD 计算进行了表征。一些分离物在体外对人甲型流感病毒（H3N2）表现出抗病毒作用。
