Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology, Beijing 100081, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
ACS Appl Mater Interfaces. 2021 May 19;13(19):22150-22158. doi: 10.1021/acsami.1c00970. Epub 2021 May 6.
Dynamic therapy, such as photodynamic therapy (PDT) or chemodynamic therapy (CDT), is one of the most promising therapeutic strategies for tumors. Integrating the advantages of near-infrared-induced PDT and CDT can potentially improve the therapeutic performance. A single primitive nanostructure, CuWO nanodots, was developed. It could generate reactive oxygen species under 808 nm light irradiation and release copper ions into the acid tumor microenvironment, thereby boosting Fenton-like reactions. The PDT and CDT would occur when the nanodots were introduced into the tumor tissue and irradiated under 808 nm light. The results of combined PDT and CDT antitumor studies showed the effective inhibition of tumor tissue growth, thereby suggesting that the nanodots are candidate agents for synergistic antitumor applications.
动态治疗，如光动力疗法（PDT）或化学动力疗法（CDT），是肿瘤最有前途的治疗策略之一。整合近红外诱导 PDT 和 CDT 的优势，有可能提高治疗效果。开发了一种单一的原始纳米结构，CuWO 纳米点。它可以在 808nm 光照射下产生活性氧，并将铜离子释放到酸性肿瘤微环境中，从而促进类芬顿反应。当纳米点被引入肿瘤组织并在 808nm 光下照射时，会发生 PDT 和 CDT。联合 PDT 和 CDT 抗肿瘤研究的结果表明，肿瘤组织的生长得到了有效抑制，这表明纳米点是协同抗肿瘤应用的候选药物。
