Yuan Simin, Ge Lianyuan, Li Yi, Wang Xiaohong, Liu Zhongyuan, Cao Yang, Yang Linglin
College of Chemical Engineering Sichuan University of Science & Engineering Zigong 643000 P. R. China
State Key Laboratory of Marine Resource Utilization in the South China Sea, Hainan University Haikou 570228 P. R. China
RSC Adv. 2025 Apr 1;15(13):9985-9996. doi: 10.1039/d4ra08791g. eCollection 2025 Mar 28.
With the growing issue of antibiotic resistance, it has become increasingly crucial to develop highly efficient antimicrobial materials. While the single-component nanozyme systems exhibited some catalytic activity, their efficiency remains suboptimal. This study presents a TiC/CuWO/Pt hybrid nanozyme composed of photothermal agents and nanozymes, which leverages the photothermal effect to enhance nanozyme activity and achieve efficient antimicrobial effects. The composite material exhibited peroxidase (POD)-like catalytic activity, effectively converting hydrogen peroxide (HO) into hydroxyl radicals (·OH). Meanwhile, the TiC/CuWO/Pt material demonstrated high photothermal conversion ability, which not only promoted the generation of ·OH under near-infrared (NIR) light irradiation, but also facilitated copper (Cu) ions release from the CuWO nanozyme, thereby further augmenting its catalytic activity. After 4 to 5 min of light irradiation, the TiC/CuWO/Pt nanozyme exhibited significant antimicrobial performance against both () and (). In summary, this work presents a TiC/CuWO/Pt nanoplatform that utilizes the photothermal effect to enhance the chemodynamic antimicrobial activity, showcasing its potential applications in antibiotic-free antimicrobial fields.
随着抗生素耐药性问题日益严重，开发高效抗菌材料变得愈发关键。虽然单组分纳米酶系统表现出一定的催化活性，但其效率仍不尽人意。本研究提出了一种由光热剂和纳米酶组成的TiC/CuWO/Pt复合纳米酶，利用光热效应增强纳米酶活性，实现高效抗菌效果。该复合材料表现出类似过氧化物酶（POD）的催化活性，能有效将过氧化氢（HO）转化为羟基自由基（·OH）。同时，TiC/CuWO/Pt材料展现出高光热转换能力，不仅在近红外（NIR）光照射下促进·OH的生成，还促使铜（Cu）离子从CuWO纳米酶中释放，从而进一步增强其催化活性。光照4至5分钟后，TiC/CuWO/Pt纳米酶对（）和（）均表现出显著的抗菌性能。总之，这项工作提出了一种利用光热效应增强化学动力学抗菌活性的TiC/CuWO/Pt纳米平台，展示了其在无抗生素抗菌领域的潜在应用。
