Departament of Preventive Medicine, Universidade Federal de São Paulo, Brazil.
Faculdade de Medicina do ABC, Santo André, Brazil.
Nutr Health. 2022 Jun;28(2):239-248. doi: 10.1177/02601060211014127. Epub 2021 May 7.
Psoriasis is a chronic, immune-mediated skin disease. It affects skin and joints, characterized by abnormal hyperproliferation of keratinocytes. The worldwide prevalence of psoriasis ranges from 2% to 4%. Environmental factors as smoking, alcohol consumption obesity can also work as triggers. During the inflammatory process, there is an exacerbated formation of free radicals and antioxidants are required to maintain redox balance.
Assess antioxidant profiles.
A cross-sectional study was conducted between August/2012 and March/2014. Sociodemographic, lifestyle, and biochemical measurements, dietary intake, serum lycopene and α-tocopherol, psoriasis severity according to Psoriasis Area and Severity Index were obtained. Comparisons between serum lycopene and α-tocopherol distributions according to variables were conducted using a one-way analysis of variance. Multiple linear regression was used to investigate factors associated with serum antioxidants.
81 participants (56% female, 62% non-white), 34% without psoriatic lesions, 51% diagnosed with mild psoriasis, and 15% with moderate psoriasis. Median (IQR) age of 54 (41, 62) years, 10 (4, 11) years of education, 17% smokers, 46% overweight and 25% obesity. In total, 72% did not reach the daily recommendation of fruit and vegetable intake. Serum lycopene and α-tocopherol were 0.2 (0.1-0.3) µmol/L and 22.5 (18.5-25.6) µmol/L, respectively. Only 14% presented adequate concentration of lycopene, but adequate α-tocopherol level was observed among 88%.
Patients reported a diet low in vegetables and fruits and rich in ultra-processed foods and fatty acids. Adequate circulating α-tocopherol but low serum lycopene, was observed among patients. A linear trend was observed for lycopene according to the severity of psoriasis.
银屑病是一种慢性、免疫介导的皮肤疾病。它影响皮肤和关节，其特征是角质形成细胞的异常过度增殖。银屑病的全球患病率在 2%至 4%之间。吸烟、饮酒、肥胖等环境因素也可能成为诱因。在炎症过程中，自由基的形成加剧，需要抗氧化剂来维持氧化还原平衡。
评估抗氧化剂谱。
本研究为 2012 年 8 月至 2014 年 3 月进行的一项横断面研究。收集社会人口统计学、生活方式和生化测量、饮食摄入、血清番茄红素和 α-生育酚、根据银屑病面积和严重程度指数（PASI）评估的银屑病严重程度等数据。采用方差分析比较血清番茄红素和 α-生育酚分布与变量的关系。采用多元线性回归分析血清抗氧化剂的相关因素。
共纳入 81 名参与者（56%为女性，62%为非白人），34%无银屑病皮损，51%诊断为轻度银屑病，15%为中度银屑病。中位（四分位间距）年龄为 54（41，62）岁，受教育年限为 10（4，11）年，17%为吸烟者，46%超重，25%肥胖。共有 72%的人未达到每日推荐的水果和蔬菜摄入量。血清番茄红素和 α-生育酚分别为 0.2（0.1，0.3）µmol/L 和 22.5（18.5，25.6）µmol/L。仅有 14%的人番茄红素浓度充足，但 88%的人 α-生育酚水平充足。
患者报告饮食中蔬菜和水果摄入不足，而超加工食品和脂肪酸摄入丰富。患者血清中α-生育酚充足，但番茄红素水平较低。银屑病严重程度与番茄红素呈线性趋势。
