一项针对意大利患有乳糜泻的儿科人群的人类白细胞抗原II类抗原研究。
A study of HLA class II antigens in an Italian paediatric population with coeliac disease.
作者信息
Morellini M, Trabace S, Mazzilli M C, Lulli P, Cappellacci S, Bonamico M, Margarit I, Gandini E
机构信息
I. Cattedra Genetica Medica, Università degli Studi La Sapienza, Roma, Italy.
出版信息
Dis Markers. 1988 Mar;6(1):23-8.
One hundred and twenty-one Italian children with coeliac disease (CD) have been compared with a control population from the same geographical area for the distribution of HLA-DR and DQ antigens. The pattern of an increase in DR3, DR7, and of heterozygotes DR5/7 was associated with an excess of heterozygotes DQw2/DQw3 in the CD population. These findings suggest that epitopes determined by specific combinations of DQ alpha and beta chains (combinatorial determinants) predispose to the disease.
121名患有乳糜泻（CD）的意大利儿童与来自同一地理区域的对照人群进行了HLA - DR和DQ抗原分布的比较。DR3、DR7增加以及杂合子DR5/7的模式与CD人群中DQw2/DQw3杂合子过多相关。这些发现表明，由DQα和β链的特定组合所决定的表位（组合决定簇）易导致该病。
Zotero 插件