Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China.
Beijing Key Laboratory of Ophthalmology and Visual Sciences, No. 1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing, 100730, People's Republic of China.
Sci Rep. 2021 May 7;11(1):9755. doi: 10.1038/s41598-021-87844-1.
Elevated intraocular pressure (IOP) is one of the main risk factors for glaucoma, and pathological changes in the lamina cribrosa (LC) may play a leading role. This study aimed to explore the influence of different IOP on LC parameters and the correlation between parameters and glaucoma severity. A total of 91 eyes were examined by swept-source OCT and divided into IOP ≥ 30 mmHg (group A), 21 mmHg ≤ IOP < 30 mmHg (group B), and normal IOP (control, group C). Clinical parameters and all LC parameters such as cup depth (CD), lamina cribrosa depth (LCD), prelaminar tissue thickness (PTT) and LC curvature index (LCCI) were used for statistical analysis. The bulk of parameters were greater in group A than in the other groups (group B, P < 0.05; group C, P < 0.001). PTT and Bruch's membrane opening minimum rim width (BMO-MRW) were thinner in group A than in group C (P < 0.01). In univariate and multivariable linear regression analysis, visual field (VF), mean retinal nerve fiber layer (RNFL) thickness, CD, LCD, PLCSD, PTT, LCCI, aLCCI, and BMO-MRW were significantly correlated with IOP changes (P < 0.05). Pearson test showed that LCD and LCCI were correlated with mean retinal nerve fiber layer (RNFL) thickness (LCD, r = - 0.420, P = 0.002; LCCI, r = - 0.449, P < 0.001) and BMO-MRW (LCD, r = - 0.245, P = 0.019; LCCI, r = - 0.345, P < 0.001). Therefore, different levels of IOP have a remarkable effect on clinical symptoms (VF, BCVA) and LC parameters, between which there may be a linear relationship. LCCI may exhibit a more significant correlation with RNFL thickness and BMO-MRW, which may further suggest that LCCI shows a better correlation with clinical symptoms under the influence of long-term high IOP.
眼压（IOP）升高是青光眼的主要危险因素之一，而筛板（LC）的病理变化可能起主导作用。本研究旨在探讨不同 IOP 对 LC 参数的影响，以及参数与青光眼严重程度的相关性。共 91 只眼接受了扫频源 OCT 检查，并分为 IOP≥30mmHg（A 组）、21mmHg≤IOP<30mmHg（B 组）和正常 IOP（对照组，C 组）。对临床参数和所有 LC 参数，如杯盘比（CD）、筛板深度（LCD）、视盘前组织厚度（PTT）和 LC 曲率指数（LCCI）进行了统计学分析。A 组的大部分参数均大于其他组（B 组，P<0.05；C 组，P<0.001）。A 组的 PTT 和 Bruch 膜开口最小 rim 宽度（BMO-MRW）比 C 组薄（P<0.01）。在单变量和多变量线性回归分析中，视野（VF）、平均视网膜神经纤维层（RNFL）厚度、CD、LCD、PLCSD、PTT、LCCI、aLCCI 和 BMO-MRW 与 IOP 变化显著相关（P<0.05）。Pearson 检验显示，LCD 和 LCCI 与平均视网膜神经纤维层（RNFL）厚度相关（LCD，r=-0.420，P=0.002；LCCI，r=-0.449，P<0.001）和 BMO-MRW（LCD，r=-0.245，P=0.019；LCCI，r=-0.345，P<0.001）。因此，不同水平的 IOP 对临床症状（VF、BCVA）和 LC 参数有显著影响，两者之间可能存在线性关系。LCCI 可能与 RNFL 厚度和 BMO-MRW 具有更显著的相关性，这可能进一步表明，在长期高眼压的影响下，LCCI 与临床症状的相关性更好。
