Departments of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Exp Mol Med. 2021 May;53(5):761-771. doi: 10.1038/s12276-021-00612-z. Epub 2021 May 7.
Cancer immune evasion is one of the hallmarks of carcinogenesis. Cancer cells employ multiple mechanisms to avoid immune recognition and suppress antitumor immune responses. Recently, accumulating evidence has indicated that immune-related pathways are epigenetically dysregulated in cancer. Most importantly, the epigenetic footprint of immune-related pathways is associated with the patient outcome, underscoring the crucial need to understand this process. In this review, we summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome.
癌症的免疫逃逸是癌症发生的标志之一。癌细胞采用多种机制来避免免疫识别并抑制抗肿瘤免疫反应。最近，越来越多的证据表明，免疫相关途径在癌症中存在表观遗传失调。最重要的是，免疫相关途径的表观遗传特征与患者的预后相关，这突显了深入了解这一过程的迫切需要。在这篇综述中，我们总结了目前关于癌症中免疫相关途径的表观遗传调控的证据，并描述了有助于破译癌症表观基因组的生物信息学工具、信息可视化技术和资源。
