Friedrich E, Etzrodt A, Becker H, Hanker J P, Keller E, Kleisl P, Pinto V, Schindler A E, Schneider H P, Vanderbeke O, Werder H, Wyss H I
Acta Endocrinol (Copenh). 1978 Jan;87(1):19-27. doi: 10.1530/acta.0.0870019.
D-Ser (TBU)6 LH-RH 1-9 (EA)10 (HOE 766) a highly active LH-RH analogue, was studied with regard to its effects on the release of follicle stimulating hormone (FSH), luteinizing hormone (LH) and oestradiol-17beta (Oe2) during the follicular phase of the menstrual cycle. Forty-two regularly menstruating women were allowed to five different treatment groups with different doses (1.25 microgram; 2.5 microgram; 5.0 microgram; 10.0 microgram; 20.0 microgram) of HOE 766 given as intravenous bolus injections and the plasma concentrations of FSH, LH and Oe2 were measured up to 24 h after injection using specific radioimmunoassays. In the majority of cases, peak values of both FSH and LH occurred 4 h after injection being significantly different from pre-injection levels (P less than 0.02 in the 1.25 microgram treatment group, P less than 0.005 for the other treatment groups). Statistical analysis of maximum values as well as the absolute and relative increase in the different treatment groups revealed a dose-dependent effect of HOE 766. Maximum values of Oe2 occurred 8 h after injection and were found to be significantly different from pre-injection levels (P less than 0.005). However, no dose dependent effect was observed. It was concluded that HOE 766 is a potent and long-acting stimulator of FSH, LH and OE2 release in women. The effect of HOE 766 is dose dependent for FSH and LH but not for Oe2.
D-丝氨酸（叔丁基）6 促黄体激素释放激素1-9 （乙基酰胺）10 （HOE 766），一种高活性促黄体激素释放激素类似物，就其在月经周期卵泡期对促卵泡激素（FSH）、促黄体生成素（LH）和雌二醇-17β（Oe2）释放的影响进行了研究。42名月经周期规律的女性被分为五个不同治疗组，静脉推注给予不同剂量（1.25微克；2.5微克；5.0微克；10.0微克；20.0微克）的HOE 766，并使用特异性放射免疫分析法在注射后长达24小时测量FSH、LH和Oe2的血浆浓度。在大多数情况下，FSH和LH的峰值在注射后4小时出现，与注射前水平有显著差异（1.25微克治疗组P<0.02，其他治疗组P<0.005）。对不同治疗组最大值以及绝对和相对增加量的统计分析显示HOE 766有剂量依赖性效应。Oe2的最大值在注射后8小时出现，且与注射前水平有显著差异（P<0.005）。然而，未观察到剂量依赖性效应。得出的结论是，HOE 766是女性FSH、LH和OE2释放的强效长效刺激剂。HOE 766对FSH和LH的作用具有剂量依赖性，但对Oe2则不然。
