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自闭症成年人的饮食、运动、睡眠、BMI 及健康状况调查。

An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults.

机构信息

Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B Trumpington Road, Cambridge, England, CB2 8AH.

MRC Epidemiology Unit and Department of Pediatrics, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus,, Cambridge, England, CB2 0QQ.

出版信息

Mol Autism. 2021 May 8;12(1):31. doi: 10.1186/s13229-021-00441-x.

Abstract

BACKGROUND

Studies of autistic children suggest that restricted eating, reduced physical activity, and sleep disorders are common; however, no studies attempt to broadly describe the diet, exercise, and sleep patterns of autistic adults or consider relationships between lifestyle behaviors and the widely reported increased risks of obesity and chronic conditions. To address this, the authors developed the largest study of lifestyle patterns of autistic adults and assessed their relationships to body mass index, health outcomes, and family history.

METHODS

We administered an anonymized, online survey to n = 2386 adults (n = 1183 autistic) aged 16-90 years of age. We employed Fisher's exact tests and binomial logistic regression to describe diet, exercise, and sleep patterns; mediation of seizure disorders on sleep; body mass index (BMI); relationships of lifestyle factors to BMI, cardiovascular conditions, and diabetic conditions; and sex differences among autistic adults.

RESULTS

Autistic adults, and particularly autistic females, exhibit unhealthy diet, exercise, and sleep patterns; they are also more likely to be underweight or obese. Limited sleep duration and high rates of sleep disturbances cannot be accounted for by epilepsy or seizure disorders. Lifestyle factors are positively related to higher risk of cardiovascular conditions among autistic males, even more than family history.

LIMITATIONS

Our sample may not be representative of all autistic and non-autistic people, as it primarily comprised individuals who are white, female, have a high school education or higher, and reside in the UK. Our sampling methods may also exclude some individuals on the autism spectrum, and particularly those with moderate to severe intellectual disability. This is a cross-sectional sample that can test for relationships between factors (e.g., lifestyle factors and health outcomes) but cannot assess the direction of these relationships.

CONCLUSIONS

Autistic adults are less likely to meet minimal health recommendations for diet, exercise, and sleep-and these unhealthy behaviors may relate to excess risk of cardiovascular conditions. Although the present study can only provide preliminary, correlational evidence, our findings suggest that diet, exercise, and sleep should be considered and further investigated as key targets for reducing the now widely reported and dramatically increased risks of health comorbidity and premature death among autistic individuals compared to others. Physicians should work cooperatively with patients to provide health education and develop individualized strategies for how to better manage challenges with diet, exercise, and sleep.

摘要

背景

对自闭症儿童的研究表明,限制进食、体力活动减少和睡眠障碍较为常见;然而,尚无研究尝试广泛描述自闭症成人的饮食、运动和睡眠模式,也未考虑生活方式行为与普遍报告的肥胖和慢性病风险增加之间的关系。为了解决这一问题,作者对自闭症成人的生活方式模式进行了最大规模的研究,并评估了这些模式与体重指数、健康结果和家族史之间的关系。

方法

我们向 2386 名年龄在 16-90 岁的成年人(1183 名自闭症成人)发放了匿名在线调查。我们采用 Fisher 确切检验和二项逻辑回归来描述饮食、运动和睡眠模式;采用中介分析癫痫发作对睡眠的影响;采用体重指数(BMI);分析生活方式因素与 BMI、心血管疾病和糖尿病之间的关系;以及自闭症成人中的性别差异。

结果

自闭症成人,尤其是自闭症女性,表现出不健康的饮食、运动和睡眠模式;他们也更有可能体重过轻或肥胖。睡眠持续时间短和睡眠障碍发生率高不能用癫痫或癫痫发作来解释。生活方式因素与自闭症男性患心血管疾病的风险增加呈正相关,甚至比家族史更明显。

局限性

我们的样本可能不能代表所有自闭症和非自闭症人群,因为它主要由白人、女性、具有高中或更高学历、居住在英国的人群组成。我们的抽样方法也可能排除一些自闭症谱系人群,尤其是那些有中度至重度智力障碍的人群。这是一个横断面样本,可用于测试因素之间的关系(例如,生活方式因素与健康结果),但不能评估这些关系的方向。

结论

自闭症成人更不可能满足饮食、运动和睡眠的最低健康建议——这些不健康的行为可能与心血管疾病的风险增加有关。尽管本研究只能提供初步的相关性证据,但我们的研究结果表明,饮食、运动和睡眠应该被视为降低自闭症患者与其他人相比现在广泛报告的、发病率明显增加的健康合并症和过早死亡风险的关键目标,并进一步研究。医生应该与患者合作,提供健康教育,并制定个性化策略,以更好地管理饮食、运动和睡眠方面的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a34/8106173/6dc132ebf591/13229_2021_441_Fig1_HTML.jpg

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