Center for the Clinical Trials Network, National Institute On Drug Abuse, National Institutes of Health, 3WFN Room 09A48 MSC 6022, 301 North Stonestreet Avenue, Bethesda, MD, 20892, USA.
Addict Sci Clin Pract. 2021 May 8;16(1):28. doi: 10.1186/s13722-021-00238-6.
Over the past two decades, the National Drug Abuse Treatment Clinical Trials Network (CTN), a program of the National Institute on Drug Abuse (NIDA), has expanded from the initial six Nodes to 16 Nodes, as a nationwide consortium of research scientists and treatment providers working together to improve care for substance use in the nation's communities. Encompassing both specialty care programs and general medical settings, the Network has become a unique resource for expertise on clinically focused research, bridging the gap between research and treatment delivery. Over 22 years, the CTN has completed 101 studies, resulting in 650 publications. In response to the opioid epidemic, a CTN task force generated a comprehensive list of research priorities in the areas of prevention, treatment, knowledge dissemination, and workforce training, to form the basis of the Network's opioid portfolio. The Network's opioid portfolio currently includes five main categories of studies: (1) large multi-site studies; (2) studies aimed at closing the treatment gap; (3) expansion of ongoing studies to improve service delivery and implementation; (4) studies to explore the use of substance use data in electronic health record systems; (5) training and dissemination projects to expand the research/health care provider workforce. With funding from the Helping to End Addiction Long-Term Initiative (HEAL), the CTN established five new Nodes, which, along with the pre-existing Nodes, are distributed in every region of the nation and engage researchers and clinicians in areas that have been among the hardest hit by the opioid epidemic. Through this expanded network and its commitment to developing personalized, evidence-based treatments, the CTN is poised to address and provide solutions for the ongoing epidemic of opioid use and addiction.
在过去的二十年中，国家药物滥用治疗临床试验网络（CTN）作为一个全国性的研究科学家和治疗提供者联盟，已经从最初的六个节点扩展到了 16 个节点，该网络是国家药物滥用研究所（NIDA）的一个项目，旨在改善全国社区的物质使用治疗。该网络涵盖了专业护理计划和一般医疗环境，已成为专注于临床研究的专业知识的独特资源，弥合了研究和治疗提供之间的差距。在 22 年多的时间里，CTN 已经完成了 101 项研究，产生了 650 篇出版物。针对阿片类药物流行，CTN 工作组制定了预防、治疗、知识传播和劳动力培训等领域的研究重点综合清单，以此作为网络阿片类药物投资组合的基础。网络的阿片类药物投资组合目前包括五个主要类别的研究：（1）大型多站点研究；（2）旨在缩小治疗差距的研究；（3）扩大正在进行的研究以改善服务提供和实施；（4）探索在电子健康记录系统中使用物质使用数据的研究；（5）培训和传播项目，以扩大研究/医疗保健提供者的劳动力。CTN 在帮助终结成瘾长期倡议（HEAL）的资助下，建立了五个新的节点，这些节点与现有的节点一起分布在全国的每个地区，让研究人员和临床医生参与到受阿片类药物流行影响最严重的领域。通过这个扩展的网络及其致力于开发个性化、基于证据的治疗方法，CTN 有望解决阿片类药物使用和成瘾的持续流行问题并提供解决方案。
