School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran; Anahita Royan Chemistry Company, Kermanshah, Iran.
School of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran.
Int J Biol Macromol. 2021 Jul 31;183:790-810. doi: 10.1016/j.ijbiomac.2021.05.009. Epub 2021 May 8.
In recent years, the incidence of cancer is increasing every day due to poor quality of life (industrialization of life). Therefore, the treatment of cancer has received much attention from therapists. So far, many anticancer drugs have been used to treat cancer patents. However, the direct use of the anticancer drugs has the adverse side effects for patents and several limitations to treat process. Natural chitosan nanofibers prepared by electrospinning method have unique properties such as high surface area, high porosity, suitable mechanical properties, nontoxicity, biocompatibility, biodegradability, biorenewable, low immunogenicity, better clinical functionality, analogue to extracellular model, and easy production in large scale. Therefore, this bio-polymer is a very suitable case to deliver of the anti-cancer drugs to treat cancer patents. In this review summarizes the electrospinning synthesis of chitosan and its therapeutic application for the various cancer treatment.
近年来，由于生活质量（生活工业化）差，癌症的发病率每天都在增加。因此，癌症的治疗受到治疗师的广泛关注。到目前为止，已经有许多抗癌药物被用于治疗癌症患者。然而，抗癌药物的直接使用会对患者产生不良的副作用，并且在治疗过程中存在一些局限性。通过静电纺丝法制备的天然壳聚糖纳米纤维具有高比表面积、高孔隙率、适宜的机械性能、无毒、生物相容性、可生物降解性、可再生性、低免疫原性、更好的临床功能、类似细胞外模型以及易于大规模生产等独特性质。因此，这种生物聚合物是一种非常适合输送抗癌药物来治疗癌症患者的材料。本文综述了壳聚糖的静电纺丝合成及其在各种癌症治疗中的治疗应用。
