使用NBS和TMSN的锰/联吡啶催化非导向C(sp)-H溴化反应
Manganese/bipyridine-catalyzed non-directed C(sp)-H bromination using NBS and TMSN.
作者信息
Sneh Kumar, Torigoe Takeru, Kuninobu Yoichiro
机构信息
Department of Molecular and Material Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1 Kasugakoen, Kasuga-shi, Fukuoka 816-8580, Japan.
Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasugakoen, Kasuga-shi, Fukuoka 816-8580, Japan.
出版信息
Beilstein J Org Chem. 2021 Apr 22;17:885-890. doi: 10.3762/bjoc.17.74. eCollection 2021.
A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp)-H bonds has been developed using -bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups.
已开发出一种使用 N-溴代琥珀酰亚胺（NBS）作为溴化试剂的 Mn(II)/联吡啶催化未活化脂肪族 C(sp³)-H 键的溴化反应。该反应即使在克级规模下也能以中等到良好的产率进行。引入的溴原子可转化为氟和烯丙基。
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