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慕尼黑德国心脏中心——成人先天性心脏病手术45年:从房间隔缺损和主动脉缩窄的初次矫正到复杂再次手术

German Heart Centre Munich-45 years of surgery in adults with congenital heart defects: from primary corrections of septal defects and coarctation to complex reoperations.

作者信息

Pabst von Ohain Jelena, Tonino Eleonora, Kaemmerer Harald, Cleuziou Julie, Ewert Peter, Lange Rüdiger, Hörer Jürgen

机构信息

Department of Congenital and Paediatric Heart Surgery, German Heart Centre Munich, Technische Universität München, Munich, Germany.

Division of Congenital and Paediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilian-Universität, Munich, Germany.

出版信息

Cardiovasc Diagn Ther. 2021 Apr;11(2):492-502. doi: 10.21037/cdt-20-831.

Abstract

BACKGROUND

Our historical overview in the form of a cohort study aimed to describe the changes in the cardiac operations in adults with congenital heart disease (ACHD), over 45 years in the German Heart Centre in Munich.

METHODS

The study population comprised all consecutive patients aged 18 or more, who underwent surgery for congenital heart disease (CHD) at the German Heart Centre Munich, between 1974 and 2018. Operations were coded according to the Adult Congenital Heart Surgery (ACHS) score. Two-tailed chi-square test was used for testing on differences in the frequency of procedural groups between the decades.

RESULTS

During the examined 45-year period, 2,882 operations were performed on ACHD. The number of operations per year increased with a correlation coefficient r=0.533, P<0.001. Overall operative mortality was 3.2%. There was no significant difference in mortality over the decades. The percentage of primary CHD diagnosis being the indication for the operation was 99% in the 1970s and decreased significantly to 56% in the 2010s, P<0.001. There was a significant decrease in the relative frequency of atrial septal defect closures from 45% in the 1970s and 1980s to 9% in 2010s (P<0.001). Coarctation repair made up 15% of all operations in the 1970s, then dropped significantly to 1% in the 2010s (P<0.001). The percentage of reoperations increased significantly from 7% in the 1970s to 50% in 2010s (P<0.001).

CONCLUSIONS

The spectrum of cardiac surgery in ACHD changed significantly over the last 45 years, from primary repair of septal defects and coarctation of the aorta in the 1970s to complex reoperations in the 2010s.

摘要

背景

我们以队列研究的形式进行的历史概述旨在描述在慕尼黑德国心脏中心45年间成人先天性心脏病(ACHD)心脏手术的变化情况。

方法

研究人群包括1974年至2018年期间在慕尼黑德国心脏中心接受先天性心脏病(CHD)手术的所有连续18岁及以上患者。手术根据成人先天性心脏手术(ACHS)评分进行编码。采用双侧卡方检验来检验不同十年间手术组频率的差异。

结果

在45年的研究期间,共对ACHD患者进行了2882例手术。每年的手术数量增加,相关系数r = 0.533,P < 0.001。总体手术死亡率为3.2%。几十年来死亡率无显著差异。20世纪70年代因原发性CHD诊断而进行手术的比例为99%,到2010年代显著降至56%,P < 0.001。房间隔缺损封堵术的相对频率从20世纪70年代和80年代的45%显著下降至2010年代的9%(P < 0.001)。缩窄修复术在20世纪70年代占所有手术的15%,然后在2010年代显著降至1%(P < 0.001)。再次手术的比例从20世纪70年代的7%显著增加至2010年代的50%(P < 0.001)。

结论

在过去45年中,ACHD心脏手术的范围发生了显著变化,从20世纪70年代的房间隔缺损和主动脉缩窄的初次修复到2010年代的复杂再次手术。

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