Meng Xiangfu, Xing Yunhui, Li Jiawen, Deng Cechuan, Li Yifei, Ren Xi, Zhang Donghui
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, China.
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States.
Front Cell Dev Biol. 2021 Apr 21;9:639299. doi: 10.3389/fcell.2021.639299. eCollection 2021.
As the material transportation system of the human body, the vascular network carries the transportation of materials and nutrients. Currently, the construction of functional microvascular networks is an urgent requirement for the development of regenerative medicine and drug screening systems. How to construct organs with functional blood vessels is the focus and challenge of tissue engineering research. Here in this review article, we first introduced the basic characteristics of blood vessels in the body and the mechanism of angiogenesis , summarized the current methods of constructing tissue blood vessels and , and focused on comparing the functions, applications and advantages of constructing different types of vascular chips to generate blood vessels. Finally, the challenges and opportunities faced by the development of this field were discussed.
作为人体的物质运输系统，血管网络承担着物质和营养的运输。目前，构建功能性微血管网络是再生医学和药物筛选系统发展的迫切需求。如何构建具有功能性血管的器官是组织工程研究的重点和挑战。在这篇综述文章中，我们首先介绍了体内血管的基本特征和血管生成机制，总结了目前构建组织血管的方法，并着重比较了构建不同类型血管芯片以生成血管的功能、应用及优势。最后，讨论了该领域发展面临的挑战与机遇。
