• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

α-烯醇化酶位于mTOR/HIF1α下游，并通过调节CST1促进甲状腺癌进展。

α-Enolase Lies Downstream of mTOR/HIF1α and Promotes Thyroid Carcinoma Progression by Regulating CST1.

作者信息

Liu Yang, Liao Lida, An Changming, Wang Xiaolei, Li Zhengjiang, Xu Zhengang, Liu Jie, Liu Shaoyan

机构信息

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Front Cell Dev Biol. 2021 Apr 21;9:670019. doi: 10.3389/fcell.2021.670019. eCollection 2021.

DOI:10.3389/fcell.2021.670019
PMID:33968941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8097056/
Abstract

Novel therapy strategies are crucial for thyroid carcinoma treatment. It is increasingly important to clarify the mechanism of thyroid carcinoma progression. Several studies demonstrate that α-Enolase (ENO1) participates in cancer development; nevertheless, the role of ENO1 in thyroid carcinoma progression remains unclear. In the present study, we found that the expression of ENO1 was upregulated in thyroid carcinoma samples. Proliferation and migration of thyroid carcinoma cells were suppressed by depletion of ENO1; conversely, ENO1 overexpression promoted thyroid carcinoma cell growth and invasion. To elucidate the mechanisms, we found that the hypoxia-related mTOR/HIF1 pathway regulated ENO1 expression. ENO1 regulated the expression of CST1; knockdown of CST1 reversed the tumorigenicity enhanced by ENO1 overexpression. Taken together, our findings provide a theoretical foundation for thyroid carcinoma treatment.

摘要

新型治疗策略对甲状腺癌的治疗至关重要。阐明甲状腺癌进展机制变得越来越重要。多项研究表明，α-烯醇化酶（ENO1）参与癌症发展；然而，ENO1在甲状腺癌进展中的作用仍不清楚。在本研究中，我们发现ENO1在甲状腺癌样本中的表达上调。ENO1的缺失抑制了甲状腺癌细胞的增殖和迁移；相反，ENO1的过表达促进了甲状腺癌细胞的生长和侵袭。为了阐明其机制，我们发现缺氧相关的mTOR/HIF1途径调节ENO1的表达。ENO1调节CST1的表达；CST1的敲低逆转了ENO1过表达增强的致瘤性。综上所述，我们的研究结果为甲状腺癌的治疗提供了理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/fcc8cee9b111/fcell-09-670019-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/caecedadb22d/fcell-09-670019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/c429387a46cc/fcell-09-670019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/8e85aa92ea4e/fcell-09-670019-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/0d8ef6c12eea/fcell-09-670019-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/c6d304771dd1/fcell-09-670019-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/15b617cb6154/fcell-09-670019-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/211a9de2015c/fcell-09-670019-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/fcc8cee9b111/fcell-09-670019-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/caecedadb22d/fcell-09-670019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/c429387a46cc/fcell-09-670019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/8e85aa92ea4e/fcell-09-670019-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/0d8ef6c12eea/fcell-09-670019-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/c6d304771dd1/fcell-09-670019-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/15b617cb6154/fcell-09-670019-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/211a9de2015c/fcell-09-670019-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e53e/8097056/fcc8cee9b111/fcell-09-670019-g008.jpg

相似文献

1
α-Enolase Lies Downstream of mTOR/HIF1α and Promotes Thyroid Carcinoma Progression by Regulating CST1.α-烯醇化酶位于mTOR/HIF1α下游，并通过调节CST1促进甲状腺癌进展。
Front Cell Dev Biol. 2021 Apr 21;9:670019. doi: 10.3389/fcell.2021.670019. eCollection 2021.
2
α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer.α-烯醇化酶通过调节结直肠癌中的AMPK/mTOR通路促进肿瘤发生和转移。
Mol Carcinog. 2017 May;56(5):1427-1437. doi: 10.1002/mc.22603. Epub 2017 Jan 12.
3
Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway.α-烯醇化酶通过FAK介导的PI3K/AKT信号通路促进非小细胞肺癌细胞的糖酵解、生长、迁移和侵袭。
J Hematol Oncol. 2015 Mar 8;8:22. doi: 10.1186/s13045-015-0117-5.
4
Alpha-enolase (ENO1), identified as an antigen to monoclonal antibody 12C7, promotes the self-renewal and malignant phenotype of lung cancer stem cells by AMPK/mTOR pathway.α-烯醇化酶（ENO1）被鉴定为单克隆抗体 12C7 的抗原，通过 AMPK/mTOR 通路促进肺癌干细胞的自我更新和恶性表型。
Stem Cell Res Ther. 2021 Feb 12;12(1):119. doi: 10.1186/s13287-021-02160-9.
5
Alpha-enolase promotes gastric cancer cell proliferation and metastasis via regulating AKT signaling pathway.α-烯醇化酶通过调控 AKT 信号通路促进胃癌细胞的增殖和转移。
Eur J Pharmacol. 2019 Feb 15;845:8-15. doi: 10.1016/j.ejphar.2018.12.035. Epub 2018 Dec 22.
6
Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines.维甲酸介导的ENO1/MBP-1基因产物下调导致甲状腺滤泡癌细胞系侵袭性降低。
J Mol Endocrinol. 2009 Mar;42(3):249-60. doi: 10.1677/JME-08-0118. Epub 2008 Dec 5.
7
α-enolase is highly expressed in liver cancer and promotes cancer cell invasion and metastasis.α-烯醇化酶在肝癌中高表达，并促进癌细胞侵袭和转移。
Oncol Lett. 2020 Nov;20(5):152. doi: 10.3892/ol.2020.12003. Epub 2020 Aug 24.
8
Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer.烯醇化酶1在肺癌细胞转化中具有不同作用，但在食管癌中并非如此。
Oncol Lett. 2020 Apr;19(4):3189-3196. doi: 10.3892/ol.2020.11427. Epub 2020 Mar 3.
9
B7-H3 promotes proliferation and migration of lung cancer cells by modulating PI3K/AKT pathway via ENO1 activity.B7-H3通过ENO1活性调节PI3K/AKT通路促进肺癌细胞的增殖和迁移。
Transl Cancer Res. 2024 Feb 29;13(2):833-846. doi: 10.21037/tcr-23-1537. Epub 2024 Feb 15.
10
CST1 Promoted Gastric Cancer Migration and Invasion Through Activating Wnt Pathway.CST1通过激活Wnt信号通路促进胃癌的迁移和侵袭。
Cancer Manag Res. 2021 Feb 24;13:1901-1907. doi: 10.2147/CMAR.S277770. eCollection 2021.

引用本文的文献

1
The regulatory roles and clinical significance of glycolysis in tumor.糖酵解在肿瘤中的调控作用及临床意义。
Cancer Commun (Lond). 2024 Jul;44(7):761-786. doi: 10.1002/cac2.12549. Epub 2024 Jun 8.
2
3-Hydroxytanshinone Inhibits the Activity of Hypoxia-Inducible Factor 1-α by Interfering with the Function of α-Enolase in the Glycolytic Pathway.3-羟基丹参酮通过干扰糖酵解途径中α-烯醇酶的功能抑制缺氧诱导因子 1-α的活性。
Molecules. 2024 May 9;29(10):2218. doi: 10.3390/molecules29102218.
3
Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.

本文引用的文献

1
Tuberous sclerosis 1 (Tsc1) mediated mTORC1 activation promotes glycolysis in tubular epithelial cells in kidney fibrosis.结节性硬化症1（Tsc1）介导的mTORC1激活促进肾纤维化中肾小管上皮细胞的糖酵解。
Kidney Int. 2020 Sep;98(3):686-698. doi: 10.1016/j.kint.2020.03.035. Epub 2020 Apr 27.
2
Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer.烯醇化酶1在肺癌细胞转化中具有不同作用，但在食管癌中并非如此。
Oncol Lett. 2020 Apr;19(4):3189-3196. doi: 10.3892/ol.2020.11427. Epub 2020 Mar 3.
3
Identification of potential key genes in gastric cancer using bioinformatics analysis.
JAK 抑制选择性抑制缺乏 IFN-γ 途径的黑色素瘤依赖于 T 细胞和宿主 TNF 信号。
Nat Commun. 2022 Aug 25;13(1):5013. doi: 10.1038/s41467-022-32754-7.
4
A Predictive Role of Autoantibodies Against the Epitope aa168-183 of ENO1 in the Occurrence of Miscarriage Related to Thyroid Autoimmunity.抗 ENO1 表位 aa168-183 自身抗体对甲状腺自身免疫相关流产发生的预测作用。
Front Immunol. 2022 May 30;13:890502. doi: 10.3389/fimmu.2022.890502. eCollection 2022.
5
Cystatin SN promotes epithelial-mesenchymal transition and serves as a prognostic biomarker in lung adenocarcinoma.半胱氨酸蛋白酶抑制剂 SN 促进肺腺癌的上皮间质转化并作为预后生物标志物。
BMC Cancer. 2022 May 30;22(1):589. doi: 10.1186/s12885-022-09685-z.
6
Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells.长链基因间非编码RNA 1278/miR-185-5p/胱抑素SN轴在喉癌细胞中的作用
J Oncol. 2022 Apr 21;2022:6406943. doi: 10.1155/2022/6406943. eCollection 2022.
7
ENO1 and Cancer.烯醇化酶1与癌症
Mol Ther Oncolytics. 2022 Jan 3;24:288-298. doi: 10.1016/j.omto.2021.12.026. eCollection 2022 Mar 17.
利用生物信息学分析鉴定胃癌中的潜在关键基因。
Biomed Rep. 2020 Apr;12(4):178-192. doi: 10.3892/br.2020.1281. Epub 2020 Feb 20.
4
Cystatin SN Affects Cell Proliferation by Regulating the ERα/PI3K/AKT/ERα Loopback Pathway in Breast Cancer.胱抑素SN通过调节乳腺癌中的ERα/PI3K/AKT/ERα反馈通路影响细胞增殖。
Onco Targets Ther. 2019 Dec 23;12:11359-11369. doi: 10.2147/OTT.S234328. eCollection 2019.
5
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.HIF1α/miR-520a-3p/AKT1/mTOR反馈促进胃癌细胞增殖和糖酵解
Cancer Manag Res. 2019 Dec 2;11:10145-10156. doi: 10.2147/CMAR.S223473. eCollection 2019.
6
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?真核生物翻译起始因子4γ1（EIF4G1）：癌症治疗干预的靶点？
Cancer Cell Int. 2019 Aug 31;19:224. doi: 10.1186/s12935-019-0947-2. eCollection 2019.
7
Upregulation of cystatin SN promotes hepatocellular carcinoma progression and predicts a poor prognosis.胱抑素 SN 的上调促进肝细胞癌的进展，并预示着预后不良。
J Cell Physiol. 2019 Dec;234(12):22623-22634. doi: 10.1002/jcp.28828. Epub 2019 May 20.
8
Gene expression profile analysis of ENO1 knockdown in gastric cancer cell line MGC-803.胃癌细胞系MGC-803中ENO1基因敲低后的基因表达谱分析
Oncol Lett. 2019 Apr;17(4):3881-3889. doi: 10.3892/ol.2019.10053. Epub 2019 Feb 19.
9
Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway.环状 RNA circNRIP1 通过 AKT1/mTOR 通路作为 microRNA-149-5p 的海绵促进胃癌进展。
Mol Cancer. 2019 Feb 4;18(1):20. doi: 10.1186/s12943-018-0935-5.
10
Alpha-enolase promotes gastric cancer cell proliferation and metastasis via regulating AKT signaling pathway.α-烯醇化酶通过调控 AKT 信号通路促进胃癌细胞的增殖和转移。
Eur J Pharmacol. 2019 Feb 15;845:8-15. doi: 10.1016/j.ejphar.2018.12.035. Epub 2018 Dec 22.