双阴性（DN）B 细胞：自身免疫中被低估的效应记忆 B 细胞亚群。
Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity.
机构信息
Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Beijing, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
出版信息
Clin Exp Immunol. 2021 Aug;205(2):119-127. doi: 10.1111/cei.13615. Epub 2021 Jun 6.
Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studied subsets, CD27 IgD B cells, also termed as double-negative (DN) B cells, have long been neglected. However, in recent years emerging evidence shows that DN B cells are unique memory B cells with important functions. They are expanded in a variety of diseases, especially in autoimmune diseases, contributing to the disease pathogenesis. Here, we briefly review the studies on DN B cells, including their origins, characteristics, subsets and roles in diseases, to try to bring new insights into this under-recognized B cell subset.
基于 CD27 和免疫球蛋白 (Ig)D 的表达，人类 B 细胞可分为四个经典亚群。与其他三个研究较为充分的亚群不同，CD27IgD B 细胞，也称为双阴性 (DN) B 细胞，长期以来一直被忽视。然而，近年来新出现的证据表明，DN B 细胞是具有重要功能的独特记忆 B 细胞。它们在多种疾病中扩增，尤其是在自身免疫性疾病中，导致疾病发病机制。在这里，我们简要回顾了关于 DN B 细胞的研究，包括其起源、特征、亚群及其在疾病中的作用，以期为这一未被充分认识的 B 细胞亚群提供新的见解。
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