Fu Yaw-Syan, Ho Wan-Yi, Kang Ning, Tsai May-Jywan, Wu Jingyi, Huang Liyue, Weng Ching-Feng
Department of Basic Medical Science, Anatomy and Functional Physiology Section, Xiamen Medical College, Xiamen, China.
Department of Basic Medical Science, Institute of Respiratory Disease, Xiamen Medical College, Xiamen, China.
Front Pharmacol. 2022 Apr 14;13:863082. doi: 10.3389/fphar.2022.863082. eCollection 2022.
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a positive-strand RNA virus, and has rapidly spread worldwide as a pandemic. The vaccines, repurposed drugs, and specific treatments have led to a surge of novel therapies and guidelines nowadays; however, the epidemic of COVID-19 is not yet fully combated and is still in a vital crisis. In repositioning drugs, natural products are gaining attention because of the large therapeutic window and potent antiviral, immunomodulatory, anti-inflammatory, and antioxidant properties. Of note, the predominant curcumoid extracted from turmeric ( L.) including phenolic curcumin influences multiple signaling pathways and has demonstrated to possess anti-inflammatory, antioxidant, antimicrobial, hypoglycemic, wound healing, chemopreventive, chemosensitizing, and radiosensitizing spectrums. In this review, all pieces of current information related to curcumin-used for the treatment and prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through , , and studies, clinical trials, and new formulation designs are retrieved to re-evaluate the applications based on the pharmaceutical efficacy of clinical therapy and to provide deep insights into knowledge and strategy about the curcumin's role as an immune booster, inflammatory modulator, and therapeutic agent against COVID-19. Moreover, this study will also afford a favorable application or approach with evidence based on the drug discovery and development, pharmacology, functional foods, and nutraceuticals for effectively fighting the COVID-19 pandemic.
2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，SARS-CoV-2是一种正链RNA病毒，已作为大流行病在全球迅速传播。疫苗、重新利用的药物和特定治疗方法导致如今新疗法和指南激增；然而，COVID-19疫情尚未得到充分抗击，仍处于关键危机之中。在重新利用药物方面，天然产物因其较大的治疗窗口以及强大的抗病毒、免疫调节、抗炎和抗氧化特性而受到关注。值得注意的是，从姜黄（L.）中提取的主要姜黄素类化合物，包括酚类姜黄素，会影响多种信号通路，并已证明具有抗炎、抗氧化、抗菌、降血糖、伤口愈合、化学预防、化学增敏和放射增敏等作用。在本综述中，检索了所有与姜黄素相关的当前信息，这些信息来自于通过 、 和 研究、临床试验以及新制剂设计用于治疗和预防严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的内容，以便根据临床治疗的药物疗效重新评估其应用，并深入了解姜黄素作为免疫增强剂、炎症调节剂和抗COVID-19治疗剂的作用的知识和策略。此外，本研究还将基于药物发现与开发、药理学、功能食品和营养保健品提供一种基于证据的有利应用或方法，以有效对抗COVID-19大流行。
